MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and...

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Autores principales:	Sean M. Flynn, Changchun Chen, Murat Artan, Stephen Barratt, Alastair Crisp, Geoffrey M. Nelson, Sew-Yeu Peak-Chew, Farida Begum, Mark Skehel, Mario de Bono
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/377402b6f41e4c2d90a5764edd0f5adf
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id	oai:doaj.org-article:377402b6f41e4c2d90a5764edd0f5adf
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spelling	oai:doaj.org-article:377402b6f41e4c2d90a5764edd0f5adf2021-12-02T14:42:33ZMALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity10.1038/s41467-020-15872-y2041-1723https://doaj.org/article/377402b6f41e4c2d90a5764edd0f5adf2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15872-yhttps://doaj.org/toc/2041-1723IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and longevity.Sean M. FlynnChangchun ChenMurat ArtanStephen BarrattAlastair CrispGeoffrey M. NelsonSew-Yeu Peak-ChewFarida BegumMark SkehelMario de BonoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sean M. Flynn Changchun Chen Murat Artan Stephen Barratt Alastair Crisp Geoffrey M. Nelson Sew-Yeu Peak-Chew Farida Begum Mark Skehel Mario de Bono MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
description	IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including escape behavior, associative learning, immunity and longevity.
format	article
author	Sean M. Flynn Changchun Chen Murat Artan Stephen Barratt Alastair Crisp Geoffrey M. Nelson Sew-Yeu Peak-Chew Farida Begum Mark Skehel Mario de Bono
author_facet	Sean M. Flynn Changchun Chen Murat Artan Stephen Barratt Alastair Crisp Geoffrey M. Nelson Sew-Yeu Peak-Chew Farida Begum Mark Skehel Mario de Bono
author_sort	Sean M. Flynn
title	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_short	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_full	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_fullStr	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_full_unstemmed	MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
title_sort	malt-1 mediates il-17 neural signaling to regulate c. elegans behavior, immunity and longevity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/377402b6f41e4c2d90a5764edd0f5adf
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MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

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