Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies

Numerous reports describe the emergence of resistance in dermatophytes, especially in <i>T. rubrum</i> and <i>T. mentagrophytes/indotineae</i> strains. We here present a review of the current status of resistance in dermatophytes worldwide. Resistance to terbinafine is mainly...

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Autores principales:	Rosalie Sacheli, Marie-Pierre Hayette
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dermatophytes resistance terbinafine azoles Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3776984b8bf54c7b8b3dc78dc8602410
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spelling	oai:doaj.org-article:3776984b8bf54c7b8b3dc78dc86024102021-11-25T18:06:31ZAntifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies10.3390/jof71109832309-608Xhttps://doaj.org/article/3776984b8bf54c7b8b3dc78dc86024102021-11-01T00:00:00Zhttps://www.mdpi.com/2309-608X/7/11/983https://doaj.org/toc/2309-608XNumerous reports describe the emergence of resistance in dermatophytes, especially in <i>T. rubrum</i> and <i>T. mentagrophytes/indotineae</i> strains. We here present a review of the current status of resistance in dermatophytes worldwide. Resistance to terbinafine is mainly discussed, with different mutations found in the squalene epoxidase gene also considered. Resistance to azoles is also approached. Clinical presentations caused by resistant dermatophytes are presented, together with alternative therapies that help to better manage these kind of infections.Rosalie SacheliMarie-Pierre HayetteMDPI AGarticledermatophytesresistanceterbinafineazolesBiology (General)QH301-705.5ENJournal of Fungi, Vol 7, Iss 983, p 983 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dermatophytes resistance terbinafine azoles Biology (General) QH301-705.5
spellingShingle	dermatophytes resistance terbinafine azoles Biology (General) QH301-705.5 Rosalie Sacheli Marie-Pierre Hayette Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies
description	Numerous reports describe the emergence of resistance in dermatophytes, especially in <i>T. rubrum</i> and <i>T. mentagrophytes/indotineae</i> strains. We here present a review of the current status of resistance in dermatophytes worldwide. Resistance to terbinafine is mainly discussed, with different mutations found in the squalene epoxidase gene also considered. Resistance to azoles is also approached. Clinical presentations caused by resistant dermatophytes are presented, together with alternative therapies that help to better manage these kind of infections.
format	article
author	Rosalie Sacheli Marie-Pierre Hayette
author_facet	Rosalie Sacheli Marie-Pierre Hayette
author_sort	Rosalie Sacheli
title	Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies
title_short	Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies
title_full	Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies
title_fullStr	Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies
title_full_unstemmed	Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies
title_sort	antifungal resistance in dermatophytes: genetic considerations, clinical presentations and alternative therapies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3776984b8bf54c7b8b3dc78dc8602410
work_keys_str_mv	AT rosaliesacheli antifungalresistanceindermatophytesgeneticconsiderationsclinicalpresentationsandalternativetherapies AT mariepierrehayette antifungalresistanceindermatophytesgeneticconsiderationsclinicalpresentationsandalternativetherapies
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Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies

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