Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

The fungal pathogen Cryptococcus neoformans can adapt to mammalian core body temperature. Here, Bloom et al. show that Ccr4-mediated decay of ribosomal protein mRNAs is important for thermotolerance and immune evasion by promoting masking of cell wall glucans.

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Autores principales:	Amanda L. M. Bloom, Richard M. Jin, Jay Leipheimer, Jonathan E. Bard, Donald Yergeau, Elizabeth A. Wohlfert, John C. Panepinto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37783490fd9b450ab6089e2c3b37ef6e
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spelling	oai:doaj.org-article:37783490fd9b450ab6089e2c3b37ef6e2021-12-02T15:35:12ZThermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming10.1038/s41467-019-12907-x2041-1723https://doaj.org/article/37783490fd9b450ab6089e2c3b37ef6e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12907-xhttps://doaj.org/toc/2041-1723The fungal pathogen Cryptococcus neoformans can adapt to mammalian core body temperature. Here, Bloom et al. show that Ccr4-mediated decay of ribosomal protein mRNAs is important for thermotolerance and immune evasion by promoting masking of cell wall glucans.Amanda L. M. BloomRichard M. JinJay LeipheimerJonathan E. BardDonald YergeauElizabeth A. WohlfertJohn C. PanepintoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amanda L. M. Bloom Richard M. Jin Jay Leipheimer Jonathan E. Bard Donald Yergeau Elizabeth A. Wohlfert John C. Panepinto Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
description	The fungal pathogen Cryptococcus neoformans can adapt to mammalian core body temperature. Here, Bloom et al. show that Ccr4-mediated decay of ribosomal protein mRNAs is important for thermotolerance and immune evasion by promoting masking of cell wall glucans.
format	article
author	Amanda L. M. Bloom Richard M. Jin Jay Leipheimer Jonathan E. Bard Donald Yergeau Elizabeth A. Wohlfert John C. Panepinto
author_facet	Amanda L. M. Bloom Richard M. Jin Jay Leipheimer Jonathan E. Bard Donald Yergeau Elizabeth A. Wohlfert John C. Panepinto
author_sort	Amanda L. M. Bloom
title	Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
title_short	Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
title_full	Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
title_fullStr	Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
title_full_unstemmed	Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
title_sort	thermotolerance in the pathogen cryptococcus neoformans is linked to antigen masking via mrna decay-dependent reprogramming
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/37783490fd9b450ab6089e2c3b37ef6e
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Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

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