Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

The fungal pathogen Cryptococcus neoformans can adapt to mammalian core body temperature. Here, Bloom et al. show that Ccr4-mediated decay of ribosomal protein mRNAs is important for thermotolerance and immune evasion by promoting masking of cell wall glucans.

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Detalles Bibliográficos
Autores principales: Amanda L. M. Bloom, Richard M. Jin, Jay Leipheimer, Jonathan E. Bard, Donald Yergeau, Elizabeth A. Wohlfert, John C. Panepinto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/37783490fd9b450ab6089e2c3b37ef6e
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