Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study

Abstract MRI can assess plaque composition and has demonstrated an association between some atherosclerotic risk factors (RF) and markers of plaque vulnerability in naive patients. We aimed at investigating this association in medically treated asymptomatic patients. This is a cross-sectional interi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Oronzo Catalano, Giulia Bendotti, Alessia Mori, Maria De Salvo, Marialuisa Falconi, Teresa L. Aloi, Valentina Tibollo, Riccardo Bellazzi, Alberto Ferrari Bardile, Stefano Montagna, Clara Pesarin, Paolo Poggi, Roberto F. E. Pedretti, Silvia G. Priori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37793f767bc749dcb79ec4c2159076e6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:37793f767bc749dcb79ec4c2159076e6
record_format	dspace
spelling	oai:doaj.org-article:37793f767bc749dcb79ec4c2159076e62021-12-02T10:48:32ZEvolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study10.1038/s41598-021-81247-y2045-2322https://doaj.org/article/37793f767bc749dcb79ec4c2159076e62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81247-yhttps://doaj.org/toc/2045-2322Abstract MRI can assess plaque composition and has demonstrated an association between some atherosclerotic risk factors (RF) and markers of plaque vulnerability in naive patients. We aimed at investigating this association in medically treated asymptomatic patients. This is a cross-sectional interim analysis (August 2013–September 2016) of a single center prospective study on carotid plaque vulnerability (MAGNETIC study). We recruited patients with asymptomatic carotid atherosclerosis (US stenosis > 30%, ECST criteria), receiving medical treatments at a tertiary cardiac rehabilitation. Atherosclerotic burden and plaque composition were quantified with 3.0 T MRI. The association between baseline characteristics and extent of lipid-rich necrotic core (LRNC), fibrous cap (CAP) and intraplaque hemorrhage (IPH) was studied with multiple regression analysis. We enrolled 260 patients (198 male, 76%) with median age of 71-y (interquartile range: 65–76). Patients were on antiplatelet therapy, ACE-inhibitors/angiotensin receptor blockers and statins (196–229, 75–88%). Median LDL-cholesterol was 78 mg/dl (59–106), blood pressure 130/70 mmHg (111–140/65–80), glycosylated hemoglobin 46 mmol/mol (39–51) and BMI 25 kg/m2 (23–28); moreover, 125 out of 187 (67%) patients were ex-smokers. Multivariate analysis of a data-set of 487 (94%) carotid arteries showed that a history of hypercholesterolemia, diabetes, hypertension or smoking did not correlate with LRNC, CAP or IPH. Conversely, maximum stenosis was the strongest independent predictor of LRNC, CAP and IPH (p < 0.001). MRI assessment of plaque composition in patients on treatment for asymptomatic carotid atherosclerosis shows no correlation between plaque vulnerability and the most well-controlled modifiable RF. Conversely, maximum stenosis exhibits a strong correlation with vulnerable features despite treatment.Oronzo CatalanoGiulia BendottiAlessia MoriMaria De SalvoMarialuisa FalconiTeresa L. AloiValentina TibolloRiccardo BellazziAlberto Ferrari BardileStefano MontagnaClara PesarinPaolo PoggiRoberto F. E. PedrettiSilvia G. PrioriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Oronzo Catalano Giulia Bendotti Alessia Mori Maria De Salvo Marialuisa Falconi Teresa L. Aloi Valentina Tibollo Riccardo Bellazzi Alberto Ferrari Bardile Stefano Montagna Clara Pesarin Paolo Poggi Roberto F. E. Pedretti Silvia G. Priori Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study
description	Abstract MRI can assess plaque composition and has demonstrated an association between some atherosclerotic risk factors (RF) and markers of plaque vulnerability in naive patients. We aimed at investigating this association in medically treated asymptomatic patients. This is a cross-sectional interim analysis (August 2013–September 2016) of a single center prospective study on carotid plaque vulnerability (MAGNETIC study). We recruited patients with asymptomatic carotid atherosclerosis (US stenosis > 30%, ECST criteria), receiving medical treatments at a tertiary cardiac rehabilitation. Atherosclerotic burden and plaque composition were quantified with 3.0 T MRI. The association between baseline characteristics and extent of lipid-rich necrotic core (LRNC), fibrous cap (CAP) and intraplaque hemorrhage (IPH) was studied with multiple regression analysis. We enrolled 260 patients (198 male, 76%) with median age of 71-y (interquartile range: 65–76). Patients were on antiplatelet therapy, ACE-inhibitors/angiotensin receptor blockers and statins (196–229, 75–88%). Median LDL-cholesterol was 78 mg/dl (59–106), blood pressure 130/70 mmHg (111–140/65–80), glycosylated hemoglobin 46 mmol/mol (39–51) and BMI 25 kg/m2 (23–28); moreover, 125 out of 187 (67%) patients were ex-smokers. Multivariate analysis of a data-set of 487 (94%) carotid arteries showed that a history of hypercholesterolemia, diabetes, hypertension or smoking did not correlate with LRNC, CAP or IPH. Conversely, maximum stenosis was the strongest independent predictor of LRNC, CAP and IPH (p < 0.001). MRI assessment of plaque composition in patients on treatment for asymptomatic carotid atherosclerosis shows no correlation between plaque vulnerability and the most well-controlled modifiable RF. Conversely, maximum stenosis exhibits a strong correlation with vulnerable features despite treatment.
format	article
author	Oronzo Catalano Giulia Bendotti Alessia Mori Maria De Salvo Marialuisa Falconi Teresa L. Aloi Valentina Tibollo Riccardo Bellazzi Alberto Ferrari Bardile Stefano Montagna Clara Pesarin Paolo Poggi Roberto F. E. Pedretti Silvia G. Priori
author_facet	Oronzo Catalano Giulia Bendotti Alessia Mori Maria De Salvo Marialuisa Falconi Teresa L. Aloi Valentina Tibollo Riccardo Bellazzi Alberto Ferrari Bardile Stefano Montagna Clara Pesarin Paolo Poggi Roberto F. E. Pedretti Silvia G. Priori
author_sort	Oronzo Catalano
title	Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study
title_short	Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study
title_full	Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study
title_fullStr	Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study
title_full_unstemmed	Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study
title_sort	evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the magnetic observational study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/37793f767bc749dcb79ec4c2159076e6
work_keys_str_mv	AT oronzocatalano evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT giuliabendotti evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT alessiamori evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT mariadesalvo evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT marialuisafalconi evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT teresalaloi evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT valentinatibollo evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT riccardobellazzi evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT albertoferraribardile evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT stefanomontagna evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT clarapesarin evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT paolopoggi evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT robertofepedretti evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy AT silviagpriori evolvingdeterminantsofcarotidatherosclerosisvulnerabilityinasymptomaticpatientsfromthemagneticobservationalstudy
_version_	1718396639617482752

Evolving determinants of carotid atherosclerosis vulnerability in asymptomatic patients from the MAGNETIC observational study

Ejemplares similares