DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer

The contribution of intra-tumour heterogeneity is increasingly associated with resistance to therapy. Here, the authors use genomic analyses to study heterogeneity in colorectal cancer and perform in-depth reconstruction of heterogeneity in one sample.

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Autores principales:	Soulafa Mamlouk, Liam Harold Childs, Daniela Aust, Daniel Heim, Friederike Melching, Cristiano Oliveira, Thomas Wolf, Pawel Durek, Dirk Schumacher, Hendrik Bläker, Moritz von Winterfeld, Bastian Gastl, Kerstin Möhr, Andrea Menne, Silke Zeugner, Torben Redmer, Dido Lenze, Sascha Tierling, Markus Möbs, Wilko Weichert, Gunnar Folprecht, Eric Blanc, Dieter Beule, Reinhold Schäfer, Markus Morkel, Frederick Klauschen, Ulf Leser, Christine Sers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/377eccf6acfe4e04830ad0acf5e3cb0e
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spelling	oai:doaj.org-article:377eccf6acfe4e04830ad0acf5e3cb0e2021-12-02T14:40:21ZDNA copy number changes define spatial patterns of heterogeneity in colorectal cancer10.1038/ncomms140932041-1723https://doaj.org/article/377eccf6acfe4e04830ad0acf5e3cb0e2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14093https://doaj.org/toc/2041-1723The contribution of intra-tumour heterogeneity is increasingly associated with resistance to therapy. Here, the authors use genomic analyses to study heterogeneity in colorectal cancer and perform in-depth reconstruction of heterogeneity in one sample.Soulafa MamloukLiam Harold ChildsDaniela AustDaniel HeimFriederike MelchingCristiano OliveiraThomas WolfPawel DurekDirk SchumacherHendrik BläkerMoritz von WinterfeldBastian GastlKerstin MöhrAndrea MenneSilke ZeugnerTorben RedmerDido LenzeSascha TierlingMarkus MöbsWilko WeichertGunnar FolprechtEric BlancDieter BeuleReinhold SchäferMarkus MorkelFrederick KlauschenUlf LeserChristine SersNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Soulafa Mamlouk Liam Harold Childs Daniela Aust Daniel Heim Friederike Melching Cristiano Oliveira Thomas Wolf Pawel Durek Dirk Schumacher Hendrik Bläker Moritz von Winterfeld Bastian Gastl Kerstin Möhr Andrea Menne Silke Zeugner Torben Redmer Dido Lenze Sascha Tierling Markus Möbs Wilko Weichert Gunnar Folprecht Eric Blanc Dieter Beule Reinhold Schäfer Markus Morkel Frederick Klauschen Ulf Leser Christine Sers DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
description	The contribution of intra-tumour heterogeneity is increasingly associated with resistance to therapy. Here, the authors use genomic analyses to study heterogeneity in colorectal cancer and perform in-depth reconstruction of heterogeneity in one sample.
format	article
author	Soulafa Mamlouk Liam Harold Childs Daniela Aust Daniel Heim Friederike Melching Cristiano Oliveira Thomas Wolf Pawel Durek Dirk Schumacher Hendrik Bläker Moritz von Winterfeld Bastian Gastl Kerstin Möhr Andrea Menne Silke Zeugner Torben Redmer Dido Lenze Sascha Tierling Markus Möbs Wilko Weichert Gunnar Folprecht Eric Blanc Dieter Beule Reinhold Schäfer Markus Morkel Frederick Klauschen Ulf Leser Christine Sers
author_facet	Soulafa Mamlouk Liam Harold Childs Daniela Aust Daniel Heim Friederike Melching Cristiano Oliveira Thomas Wolf Pawel Durek Dirk Schumacher Hendrik Bläker Moritz von Winterfeld Bastian Gastl Kerstin Möhr Andrea Menne Silke Zeugner Torben Redmer Dido Lenze Sascha Tierling Markus Möbs Wilko Weichert Gunnar Folprecht Eric Blanc Dieter Beule Reinhold Schäfer Markus Morkel Frederick Klauschen Ulf Leser Christine Sers
author_sort	Soulafa Mamlouk
title	DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
title_short	DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
title_full	DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
title_fullStr	DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
title_full_unstemmed	DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
title_sort	dna copy number changes define spatial patterns of heterogeneity in colorectal cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/377eccf6acfe4e04830ad0acf5e3cb0e
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DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer

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