Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers

Abstract DNA-water interactions have revealed as very important actor in DNA mechanics, from the molecular to the macroscopic scale. Given the particularly useful properties of DNA molecules to engineer novel materials through self-assembly and by bridging organic and inorganic materials, the intere...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carmen M. Domínguez, Daniel Ramos, Jesús I. Mendieta-Moreno, José L. G. Fierro, Jesús Mendieta, Javier Tamayo, Montserrat Calleja
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/377f15fe5e094ac585a372b850351d82
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:377f15fe5e094ac585a372b850351d82
record_format	dspace
spelling	oai:doaj.org-article:377f15fe5e094ac585a372b850351d822021-12-02T16:08:20ZEffect of water-DNA interactions on elastic properties of DNA self-assembled monolayers10.1038/s41598-017-00605-x2045-2322https://doaj.org/article/377f15fe5e094ac585a372b850351d822017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00605-xhttps://doaj.org/toc/2045-2322Abstract DNA-water interactions have revealed as very important actor in DNA mechanics, from the molecular to the macroscopic scale. Given the particularly useful properties of DNA molecules to engineer novel materials through self-assembly and by bridging organic and inorganic materials, the interest in understanding DNA elasticity has crossed the boundaries of life science to reach also materials science and engineering. Here we show that thin films of DNA constructed through the self-assembly of sulfur tethered ssDNA strands demonstrate a Young’s modulus tuning range of about 10 GPa by simply varying the environment relative humidity from 0% up to 70%. We observe that the highest tuning range occurs for ssDNA grafting densities of about 3.5 × 1013 molecules/cm 2, where the distance between the molecules maximizes the water mediated interactions between the strands. Upon hybridization with the complementary strand, the DNA self-assembled monolayers significantly soften by one order of magnitude and their Young’s modulus dependency on the hydration state drastically decreases. The experimental observations are in agreement with molecular dynamics simulations.Carmen M. DomínguezDaniel RamosJesús I. Mendieta-MorenoJosé L. G. FierroJesús MendietaJavier TamayoMontserrat CallejaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carmen M. Domínguez Daniel Ramos Jesús I. Mendieta-Moreno José L. G. Fierro Jesús Mendieta Javier Tamayo Montserrat Calleja Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers
description	Abstract DNA-water interactions have revealed as very important actor in DNA mechanics, from the molecular to the macroscopic scale. Given the particularly useful properties of DNA molecules to engineer novel materials through self-assembly and by bridging organic and inorganic materials, the interest in understanding DNA elasticity has crossed the boundaries of life science to reach also materials science and engineering. Here we show that thin films of DNA constructed through the self-assembly of sulfur tethered ssDNA strands demonstrate a Young’s modulus tuning range of about 10 GPa by simply varying the environment relative humidity from 0% up to 70%. We observe that the highest tuning range occurs for ssDNA grafting densities of about 3.5 × 1013 molecules/cm 2, where the distance between the molecules maximizes the water mediated interactions between the strands. Upon hybridization with the complementary strand, the DNA self-assembled monolayers significantly soften by one order of magnitude and their Young’s modulus dependency on the hydration state drastically decreases. The experimental observations are in agreement with molecular dynamics simulations.
format	article
author	Carmen M. Domínguez Daniel Ramos Jesús I. Mendieta-Moreno José L. G. Fierro Jesús Mendieta Javier Tamayo Montserrat Calleja
author_facet	Carmen M. Domínguez Daniel Ramos Jesús I. Mendieta-Moreno José L. G. Fierro Jesús Mendieta Javier Tamayo Montserrat Calleja
author_sort	Carmen M. Domínguez
title	Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers
title_short	Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers
title_full	Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers
title_fullStr	Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers
title_full_unstemmed	Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers
title_sort	effect of water-dna interactions on elastic properties of dna self-assembled monolayers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/377f15fe5e094ac585a372b850351d82
work_keys_str_mv	AT carmenmdominguez effectofwaterdnainteractionsonelasticpropertiesofdnaselfassembledmonolayers AT danielramos effectofwaterdnainteractionsonelasticpropertiesofdnaselfassembledmonolayers AT jesusimendietamoreno effectofwaterdnainteractionsonelasticpropertiesofdnaselfassembledmonolayers AT joselgfierro effectofwaterdnainteractionsonelasticpropertiesofdnaselfassembledmonolayers AT jesusmendieta effectofwaterdnainteractionsonelasticpropertiesofdnaselfassembledmonolayers AT javiertamayo effectofwaterdnainteractionsonelasticpropertiesofdnaselfassembledmonolayers AT montserratcalleja effectofwaterdnainteractionsonelasticpropertiesofdnaselfassembledmonolayers
_version_	1718384521747890176

Effect of water-DNA interactions on elastic properties of DNA self-assembled monolayers

Ejemplares similares