Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis

Over the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-analysis was to evaluate the association of EBV wit...

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Autores principales:	Marcos Antonio Pereira de Lima, Álife Diêgo Lima Silva, Antônio Carlos Silva do Nascimento Filho, Thiago Lima Cordeiro, João Pedro de Souza Bezerra, Maria Aline Barroso Rocha, Sally de França Lacerda Pinheiro, Roberto Flávio Fontenelle Pinheiro Junior, Maria do Socorro Vieira Gadelha, Cláudio Gleidiston Lima da Silva
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Epstein-Barr virus (EBV) laryngeal carcinoma carcinogenesis oncovirus Medicine R
Acceso en línea:	https://doaj.org/article/3781b08378954dafbec18c1c953bca8a
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spelling	oai:doaj.org-article:3781b08378954dafbec18c1c953bca8a2021-11-25T18:38:12ZEpstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis10.3390/pathogens101114292076-0817https://doaj.org/article/3781b08378954dafbec18c1c953bca8a2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1429https://doaj.org/toc/2076-0817Over the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-analysis was to evaluate the association of EBV with laryngeal carcinoma. The search was carried out in two databases, Scopus and PubMed, using the following terms: “Epstein-Barr virus” and “laryngeal carcinoma”. A total of 187 records were found, of which 31 were selected for meeting the inclusion and exclusion criteria. The meta-analysis yielded an overall pooled prevalence of 43.72% (95% confidence interval (CI): 34.35–53.08). Studies carried out in Europe and Eurasia had slightly higher pooled prevalence than other subgroups, while the prevalence of studies performed in developed countries was higher than in developing countries (46.37% vs. 34.02%). Furthermore, laryngeal carcinoma occurred almost three times as often among EBV-infected individuals compared to those without EBV infection (odds ratio = 2.86 (95% CI: 1.18–6.90); Begg’s test, <i>p</i> = 0.843 and Egger’s test, <i>p</i> = 0.866). Our findings support the idea that EBV is related to laryngeal carcinoma. However, further studies are needed before recognizing a definitive etiological role of EBV in the development and/or progression of laryngeal carcinomas.Marcos Antonio Pereira de LimaÁlife Diêgo Lima SilvaAntônio Carlos Silva do Nascimento FilhoThiago Lima CordeiroJoão Pedro de Souza BezerraMaria Aline Barroso RochaSally de França Lacerda PinheiroRoberto Flávio Fontenelle Pinheiro JuniorMaria do Socorro Vieira GadelhaCláudio Gleidiston Lima da SilvaMDPI AGarticleEpstein-Barr virus (EBV)laryngeal carcinomacarcinogenesisoncovirusMedicineRENPathogens, Vol 10, Iss 1429, p 1429 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epstein-Barr virus (EBV) laryngeal carcinoma carcinogenesis oncovirus Medicine R
spellingShingle	Epstein-Barr virus (EBV) laryngeal carcinoma carcinogenesis oncovirus Medicine R Marcos Antonio Pereira de Lima Álife Diêgo Lima Silva Antônio Carlos Silva do Nascimento Filho Thiago Lima Cordeiro João Pedro de Souza Bezerra Maria Aline Barroso Rocha Sally de França Lacerda Pinheiro Roberto Flávio Fontenelle Pinheiro Junior Maria do Socorro Vieira Gadelha Cláudio Gleidiston Lima da Silva Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis
description	Over the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-analysis was to evaluate the association of EBV with laryngeal carcinoma. The search was carried out in two databases, Scopus and PubMed, using the following terms: “Epstein-Barr virus” and “laryngeal carcinoma”. A total of 187 records were found, of which 31 were selected for meeting the inclusion and exclusion criteria. The meta-analysis yielded an overall pooled prevalence of 43.72% (95% confidence interval (CI): 34.35–53.08). Studies carried out in Europe and Eurasia had slightly higher pooled prevalence than other subgroups, while the prevalence of studies performed in developed countries was higher than in developing countries (46.37% vs. 34.02%). Furthermore, laryngeal carcinoma occurred almost three times as often among EBV-infected individuals compared to those without EBV infection (odds ratio = 2.86 (95% CI: 1.18–6.90); Begg’s test, <i>p</i> = 0.843 and Egger’s test, <i>p</i> = 0.866). Our findings support the idea that EBV is related to laryngeal carcinoma. However, further studies are needed before recognizing a definitive etiological role of EBV in the development and/or progression of laryngeal carcinomas.
format	article
author	Marcos Antonio Pereira de Lima Álife Diêgo Lima Silva Antônio Carlos Silva do Nascimento Filho Thiago Lima Cordeiro João Pedro de Souza Bezerra Maria Aline Barroso Rocha Sally de França Lacerda Pinheiro Roberto Flávio Fontenelle Pinheiro Junior Maria do Socorro Vieira Gadelha Cláudio Gleidiston Lima da Silva
author_facet	Marcos Antonio Pereira de Lima Álife Diêgo Lima Silva Antônio Carlos Silva do Nascimento Filho Thiago Lima Cordeiro João Pedro de Souza Bezerra Maria Aline Barroso Rocha Sally de França Lacerda Pinheiro Roberto Flávio Fontenelle Pinheiro Junior Maria do Socorro Vieira Gadelha Cláudio Gleidiston Lima da Silva
author_sort	Marcos Antonio Pereira de Lima
title	Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis
title_short	Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis
title_full	Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis
title_fullStr	Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis
title_full_unstemmed	Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis
title_sort	epstein-barr virus-associated carcinoma of the larynx: a systematic review with meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3781b08378954dafbec18c1c953bca8a
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Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis

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