Association Between the Rate of Treatment Response and Short-Term Outcomes in Childhood Guillain-Barré Syndrome

Introduction: Few studies have examined the association between the rate of treatment response and the outcome of pediatric Guillain-Barré syndrome (GBS). Therefore, our study aimed to identify treatment response in relation to the short-term outcomes of GBS. Further, we investigated its potential p...

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Autores principales:	Mei Jin, Libo Zhao, Jing Liu, Weijin Geng, Ziwei Zhao, Chunzhen Li, Jingru Xue, Suzhen Sun
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Guillain-Barré syndrome children treatment response rate Hughes Functional Grading Scale short-term outcomes Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/3781c1796065467f9eee88b9a59e97b2
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spelling	oai:doaj.org-article:3781c1796065467f9eee88b9a59e97b22021-11-05T08:29:30ZAssociation Between the Rate of Treatment Response and Short-Term Outcomes in Childhood Guillain-Barré Syndrome1664-229510.3389/fneur.2021.746389https://doaj.org/article/3781c1796065467f9eee88b9a59e97b22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.746389/fullhttps://doaj.org/toc/1664-2295Introduction: Few studies have examined the association between the rate of treatment response and the outcome of pediatric Guillain-Barré syndrome (GBS). Therefore, our study aimed to identify treatment response in relation to the short-term outcomes of GBS. Further, we investigated its potential predictive value for prognosis.Methods: Our retrospective study included children diagnosed with GBS in the Pediatric Neurology Department of the Children's Hospital of Hebei Province from 2016 to 2020. According to the rate of response from the standard intravenous immunoglobulin (IVIg) treatment, patients were divided into two groups: rapid-response GBS (initial response within 7 days) and slow-response (initial response within 8–30 days). The GBS disability score (Hughes Functional Grading Scale) was used to assess the children's functional disability at nadir, 1 month, and 6 months after onset.Results: Among the 36 children included in the study, 18 (50%) and 18 (50%) were rapid and slow responders, respectively. Time from IVIg treatment to the initial response was significantly shorter in the rapid-response group (5 [3–6.25] days vs. 10.5[8.75–15] days in slow-response GBS, p < 0.001). Hughes score at 1 month was worse than the rapid responders (Fisher's exact test, p = 0.006). Survival analysis (Kaplan–Meier) with respect to regaining the ability to walk independently (Hughes Functional Grading Scale of 2) within 1 month after onset was significantly different among the two groups (log-rank test for trend, p = 0.024). The abnormal levels of cerebral spinal fluid proteins and autonomic dysfunction were more frequent in the slow-response group than those in the rapid group (p < 0.05).Conclusion: The rate of response to IVIg treatment was correlated with short-term outcomes in children with GBS and had predictive value for prognosis. The role of patient's initial responses to treatment could be significantly valuable in developing more effective and efficient treatment options.Mei JinMei JinLibo ZhaoJing LiuWeijin GengZiwei ZhaoChunzhen LiJingru XueSuzhen SunFrontiers Media S.A.articleGuillain-Barré syndromechildrentreatment response rateHughes Functional Grading Scaleshort-term outcomesNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Guillain-Barré syndrome children treatment response rate Hughes Functional Grading Scale short-term outcomes Neurology. Diseases of the nervous system RC346-429
spellingShingle	Guillain-Barré syndrome children treatment response rate Hughes Functional Grading Scale short-term outcomes Neurology. Diseases of the nervous system RC346-429 Mei Jin Mei Jin Libo Zhao Jing Liu Weijin Geng Ziwei Zhao Chunzhen Li Jingru Xue Suzhen Sun Association Between the Rate of Treatment Response and Short-Term Outcomes in Childhood Guillain-Barré Syndrome
description	Introduction: Few studies have examined the association between the rate of treatment response and the outcome of pediatric Guillain-Barré syndrome (GBS). Therefore, our study aimed to identify treatment response in relation to the short-term outcomes of GBS. Further, we investigated its potential predictive value for prognosis.Methods: Our retrospective study included children diagnosed with GBS in the Pediatric Neurology Department of the Children's Hospital of Hebei Province from 2016 to 2020. According to the rate of response from the standard intravenous immunoglobulin (IVIg) treatment, patients were divided into two groups: rapid-response GBS (initial response within 7 days) and slow-response (initial response within 8–30 days). The GBS disability score (Hughes Functional Grading Scale) was used to assess the children's functional disability at nadir, 1 month, and 6 months after onset.Results: Among the 36 children included in the study, 18 (50%) and 18 (50%) were rapid and slow responders, respectively. Time from IVIg treatment to the initial response was significantly shorter in the rapid-response group (5 [3–6.25] days vs. 10.5[8.75–15] days in slow-response GBS, p < 0.001). Hughes score at 1 month was worse than the rapid responders (Fisher's exact test, p = 0.006). Survival analysis (Kaplan–Meier) with respect to regaining the ability to walk independently (Hughes Functional Grading Scale of 2) within 1 month after onset was significantly different among the two groups (log-rank test for trend, p = 0.024). The abnormal levels of cerebral spinal fluid proteins and autonomic dysfunction were more frequent in the slow-response group than those in the rapid group (p < 0.05).Conclusion: The rate of response to IVIg treatment was correlated with short-term outcomes in children with GBS and had predictive value for prognosis. The role of patient's initial responses to treatment could be significantly valuable in developing more effective and efficient treatment options.
format	article
author	Mei Jin Mei Jin Libo Zhao Jing Liu Weijin Geng Ziwei Zhao Chunzhen Li Jingru Xue Suzhen Sun
author_facet	Mei Jin Mei Jin Libo Zhao Jing Liu Weijin Geng Ziwei Zhao Chunzhen Li Jingru Xue Suzhen Sun
author_sort	Mei Jin
title	Association Between the Rate of Treatment Response and Short-Term Outcomes in Childhood Guillain-Barré Syndrome
title_short	Association Between the Rate of Treatment Response and Short-Term Outcomes in Childhood Guillain-Barré Syndrome
title_full	Association Between the Rate of Treatment Response and Short-Term Outcomes in Childhood Guillain-Barré Syndrome
title_fullStr	Association Between the Rate of Treatment Response and Short-Term Outcomes in Childhood Guillain-Barré Syndrome
title_full_unstemmed	Association Between the Rate of Treatment Response and Short-Term Outcomes in Childhood Guillain-Barré Syndrome
title_sort	association between the rate of treatment response and short-term outcomes in childhood guillain-barré syndrome
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3781c1796065467f9eee88b9a59e97b2
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Association Between the Rate of Treatment Response and Short-Term Outcomes in Childhood Guillain-Barré Syndrome

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