Evidence of a new hidden neural network into deep fasciae

Abstract It is recognized that different fasciae have different type of innervation, but actually nothing is known about the specific innervation of the two types of deep fascia, aponeurotic and epymisial fascia. In this work the aponeurotic thoracolumbar fascia and the epymisial gluteal fascia of s...

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Autores principales:	Caterina Fede, Lucia Petrelli, Diego Guidolin, Andrea Porzionato, Carmelo Pirri, Chenglei Fan, Raffaele De Caro, Carla Stecco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3785eba88b0f49ffbb22c6e51e546523
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spelling	oai:doaj.org-article:3785eba88b0f49ffbb22c6e51e5465232021-12-02T16:04:13ZEvidence of a new hidden neural network into deep fasciae10.1038/s41598-021-92194-z2045-2322https://doaj.org/article/3785eba88b0f49ffbb22c6e51e5465232021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92194-zhttps://doaj.org/toc/2045-2322Abstract It is recognized that different fasciae have different type of innervation, but actually nothing is known about the specific innervation of the two types of deep fascia, aponeurotic and epymisial fascia. In this work the aponeurotic thoracolumbar fascia and the epymisial gluteal fascia of seven adult C57-BL mice were analysed by Transmission Electron Microscopy and floating immunohistochemistry with the aim to study the organization of nerve fibers, the presence of nerve corpuscles and the amount of autonomic innervation. The antibodies used were Anti-S100, Anti-Tyrosine Hydroxylase and Anti-PGP, specific for the Schwann cells forming myelin, the sympathetic nerve fibers, and the peripheral nerve fibers, respectively. The results showed that the fascial tissue is pervaded by a rhomboid and dense network of nerves. The innervation was statistically significantly lower in the gluteal fascia (2.78 ± 0.6% of positive area, 140.3 ± 31.6/mm2 branching points, nerves with 3.2 ± 0.6 mm length and 4.9 ± 0.2 µm thickness) with respect to the thoracolumbar fascia (9.01 ± 0.98% of innervated area, 500.9 ± 43.1 branching points/mm2, length of 87.1 ± 1.0 mm, thickness of 5.8 ± 0.2 µm). Both fasciae revealed the same density of autonomic nerve fibers (0.08%). Lastly, corpuscles were not found in thoracolumbar fascia. Based on these results, it is suggested that the two fasciae have different roles in proprioception and pain perception: the free nerve endings inside thoracolumbar fascia may function as proprioceptors, regulating the tensions coming from associated muscles and having a role in nonspecific low back pain, whereas the epymisial fasciae works to coordinate the actions of the various motor units of the underlying muscle.Caterina FedeLucia PetrelliDiego GuidolinAndrea PorzionatoCarmelo PirriChenglei FanRaffaele De CaroCarla SteccoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caterina Fede Lucia Petrelli Diego Guidolin Andrea Porzionato Carmelo Pirri Chenglei Fan Raffaele De Caro Carla Stecco Evidence of a new hidden neural network into deep fasciae
description	Abstract It is recognized that different fasciae have different type of innervation, but actually nothing is known about the specific innervation of the two types of deep fascia, aponeurotic and epymisial fascia. In this work the aponeurotic thoracolumbar fascia and the epymisial gluteal fascia of seven adult C57-BL mice were analysed by Transmission Electron Microscopy and floating immunohistochemistry with the aim to study the organization of nerve fibers, the presence of nerve corpuscles and the amount of autonomic innervation. The antibodies used were Anti-S100, Anti-Tyrosine Hydroxylase and Anti-PGP, specific for the Schwann cells forming myelin, the sympathetic nerve fibers, and the peripheral nerve fibers, respectively. The results showed that the fascial tissue is pervaded by a rhomboid and dense network of nerves. The innervation was statistically significantly lower in the gluteal fascia (2.78 ± 0.6% of positive area, 140.3 ± 31.6/mm2 branching points, nerves with 3.2 ± 0.6 mm length and 4.9 ± 0.2 µm thickness) with respect to the thoracolumbar fascia (9.01 ± 0.98% of innervated area, 500.9 ± 43.1 branching points/mm2, length of 87.1 ± 1.0 mm, thickness of 5.8 ± 0.2 µm). Both fasciae revealed the same density of autonomic nerve fibers (0.08%). Lastly, corpuscles were not found in thoracolumbar fascia. Based on these results, it is suggested that the two fasciae have different roles in proprioception and pain perception: the free nerve endings inside thoracolumbar fascia may function as proprioceptors, regulating the tensions coming from associated muscles and having a role in nonspecific low back pain, whereas the epymisial fasciae works to coordinate the actions of the various motor units of the underlying muscle.
format	article
author	Caterina Fede Lucia Petrelli Diego Guidolin Andrea Porzionato Carmelo Pirri Chenglei Fan Raffaele De Caro Carla Stecco
author_facet	Caterina Fede Lucia Petrelli Diego Guidolin Andrea Porzionato Carmelo Pirri Chenglei Fan Raffaele De Caro Carla Stecco
author_sort	Caterina Fede
title	Evidence of a new hidden neural network into deep fasciae
title_short	Evidence of a new hidden neural network into deep fasciae
title_full	Evidence of a new hidden neural network into deep fasciae
title_fullStr	Evidence of a new hidden neural network into deep fasciae
title_full_unstemmed	Evidence of a new hidden neural network into deep fasciae
title_sort	evidence of a new hidden neural network into deep fasciae
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3785eba88b0f49ffbb22c6e51e546523
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_version_	1718385264902012928

Evidence of a new hidden neural network into deep fasciae

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