Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis

Fan Gao,1 Chen Chen,2 Jun Lyu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian-Feng Han2 1Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Neurology, The First...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gao F, Chen C, Lyu J, Zheng J, Ma XC, Yuan XY, Huo K, Han JF
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://doaj.org/article/37871022a5b944eb94c84a40c6d59ef5
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:37871022a5b944eb94c84a40c6d59ef5
record_format dspace
spelling oai:doaj.org-article:37871022a5b944eb94c84a40c6d59ef52021-12-02T03:35:24ZAssociation between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis1178-2021https://doaj.org/article/37871022a5b944eb94c84a40c6d59ef52018-09-01T00:00:00Zhttps://www.dovepress.com/association-between-platelet-distribution-width-and-poor-outcome-of-ac-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Fan Gao,1 Chen Chen,2 Jun Lyu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian-Feng Han2 1Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Purpose: The platelet distribution width (PDW) reflects the status of platelet activity and may be useful for early predictions of the clinical outcome of stroke patients. The purpose of the study was to determine the associations between PDW and clinical outcomes after intravenous thrombolysis in stroke patients. Patients and methods: Acute ischemic stroke patients who received intravenous treatment with recombinant tissue-type plasminogen activator were selected for inclusion in the retrospective cohort of this study. The relations between PDW at admission and clinical outcomes were analyzed, including a poor outcome as assessed using the modified Rankin Scale at 3 months, early neurological improvement, and any hemorrhage. The effect of PDW at admission on a poor outcome at 3 months was analyzed using a multivariable logistic regression model with adjustment for potential confounders. The optimal PDW cutoff for predicting poor outcome at 3 months was determined by analyzing the receiver operating characteristics curve. Results: PDW was significantly higher for a good outcome than a poor outcome (p=0.005), with median (interquartile range) values of 16.2 (13.2–17.2) and 13.6 (12.5–15.9), respectively. PDW was also higher in patients with early neurological improvement than in patients without improvement (p=0.020) and did not differ between hemorrhage and nonhemorrhage patients. The association between PDW <16.05% and poor outcome remained in a multivariable logistic regression analysis, with an OR of 6.68 and a 95% CI of 1.69–26.49 (p=0.007). Conclusion: Results suggest a novel hypothesis that a lower PDW may be related with a poor outcome at 3 months after intravenous thrombolysis in acute ischemic stroke patients. Keywords: acute ischemic stroke, platelet distribution width, intravenous thrombolysis, prognosisGao FChen CLyu JZheng JMa XCYuan XYHuo KHan JFDove Medical Pressarticleacute ischemic strokeplatelet distribution widthintravenous thrombolysisprognosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2233-2239 (2018)
institution DOAJ
collection DOAJ
language EN
topic acute ischemic stroke
platelet distribution width
intravenous thrombolysis
prognosis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle acute ischemic stroke
platelet distribution width
intravenous thrombolysis
prognosis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Gao F
Chen C
Lyu J
Zheng J
Ma XC
Yuan XY
Huo K
Han JF
Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis
description Fan Gao,1 Chen Chen,2 Jun Lyu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian-Feng Han2 1Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Purpose: The platelet distribution width (PDW) reflects the status of platelet activity and may be useful for early predictions of the clinical outcome of stroke patients. The purpose of the study was to determine the associations between PDW and clinical outcomes after intravenous thrombolysis in stroke patients. Patients and methods: Acute ischemic stroke patients who received intravenous treatment with recombinant tissue-type plasminogen activator were selected for inclusion in the retrospective cohort of this study. The relations between PDW at admission and clinical outcomes were analyzed, including a poor outcome as assessed using the modified Rankin Scale at 3 months, early neurological improvement, and any hemorrhage. The effect of PDW at admission on a poor outcome at 3 months was analyzed using a multivariable logistic regression model with adjustment for potential confounders. The optimal PDW cutoff for predicting poor outcome at 3 months was determined by analyzing the receiver operating characteristics curve. Results: PDW was significantly higher for a good outcome than a poor outcome (p=0.005), with median (interquartile range) values of 16.2 (13.2–17.2) and 13.6 (12.5–15.9), respectively. PDW was also higher in patients with early neurological improvement than in patients without improvement (p=0.020) and did not differ between hemorrhage and nonhemorrhage patients. The association between PDW <16.05% and poor outcome remained in a multivariable logistic regression analysis, with an OR of 6.68 and a 95% CI of 1.69–26.49 (p=0.007). Conclusion: Results suggest a novel hypothesis that a lower PDW may be related with a poor outcome at 3 months after intravenous thrombolysis in acute ischemic stroke patients. Keywords: acute ischemic stroke, platelet distribution width, intravenous thrombolysis, prognosis
format article
author Gao F
Chen C
Lyu J
Zheng J
Ma XC
Yuan XY
Huo K
Han JF
author_facet Gao F
Chen C
Lyu J
Zheng J
Ma XC
Yuan XY
Huo K
Han JF
author_sort Gao F
title Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis
title_short Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis
title_full Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis
title_fullStr Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis
title_full_unstemmed Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis
title_sort association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/37871022a5b944eb94c84a40c6d59ef5
work_keys_str_mv AT gaof associationbetweenplateletdistributionwidthandpooroutcomeofacuteischemicstrokeafterintravenousthrombolysis
AT chenc associationbetweenplateletdistributionwidthandpooroutcomeofacuteischemicstrokeafterintravenousthrombolysis
AT lyuj associationbetweenplateletdistributionwidthandpooroutcomeofacuteischemicstrokeafterintravenousthrombolysis
AT zhengj associationbetweenplateletdistributionwidthandpooroutcomeofacuteischemicstrokeafterintravenousthrombolysis
AT maxc associationbetweenplateletdistributionwidthandpooroutcomeofacuteischemicstrokeafterintravenousthrombolysis
AT yuanxy associationbetweenplateletdistributionwidthandpooroutcomeofacuteischemicstrokeafterintravenousthrombolysis
AT huok associationbetweenplateletdistributionwidthandpooroutcomeofacuteischemicstrokeafterintravenousthrombolysis
AT hanjf associationbetweenplateletdistributionwidthandpooroutcomeofacuteischemicstrokeafterintravenousthrombolysis
_version_ 1718401722739589120