Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

Small molecule metabolites like phenylalanine can form amyloid-like structures but so far this has only been demonstrated in vitro. Here the authors generate a yeast in vivo model of adenine self-assembly and characterize the adenine assemblies in cells by indicative amyloid dye and anti-adenine ass...

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Autores principales:	Dana Laor, Dorin Sade, Shira Shaham-Niv, Dor Zaguri, Myra Gartner, Vasantha Basavalingappa, Avi Raveh, Edward Pichinuk, Hamutal Engel, Keita Iwasaki, Tatsuyuki Yamamoto, Hemanth Noothalapati, Ehud Gazit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/378a668465b54f94a2144b2dc009b093
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spelling	oai:doaj.org-article:378a668465b54f94a2144b2dc009b0932021-12-02T15:35:59ZFibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation10.1038/s41467-018-07966-52041-1723https://doaj.org/article/378a668465b54f94a2144b2dc009b0932019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07966-5https://doaj.org/toc/2041-1723Small molecule metabolites like phenylalanine can form amyloid-like structures but so far this has only been demonstrated in vitro. Here the authors generate a yeast in vivo model of adenine self-assembly and characterize the adenine assemblies in cells by indicative amyloid dye and anti-adenine assemblies antibodies.Dana LaorDorin SadeShira Shaham-NivDor ZaguriMyra GartnerVasantha BasavalingappaAvi RavehEdward PichinukHamutal EngelKeita IwasakiTatsuyuki YamamotoHemanth NoothalapatiEhud GazitNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dana Laor Dorin Sade Shira Shaham-Niv Dor Zaguri Myra Gartner Vasantha Basavalingappa Avi Raveh Edward Pichinuk Hamutal Engel Keita Iwasaki Tatsuyuki Yamamoto Hemanth Noothalapati Ehud Gazit Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
description	Small molecule metabolites like phenylalanine can form amyloid-like structures but so far this has only been demonstrated in vitro. Here the authors generate a yeast in vivo model of adenine self-assembly and characterize the adenine assemblies in cells by indicative amyloid dye and anti-adenine assemblies antibodies.
format	article
author	Dana Laor Dorin Sade Shira Shaham-Niv Dor Zaguri Myra Gartner Vasantha Basavalingappa Avi Raveh Edward Pichinuk Hamutal Engel Keita Iwasaki Tatsuyuki Yamamoto Hemanth Noothalapati Ehud Gazit
author_facet	Dana Laor Dorin Sade Shira Shaham-Niv Dor Zaguri Myra Gartner Vasantha Basavalingappa Avi Raveh Edward Pichinuk Hamutal Engel Keita Iwasaki Tatsuyuki Yamamoto Hemanth Noothalapati Ehud Gazit
author_sort	Dana Laor
title	Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
title_short	Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
title_full	Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
title_fullStr	Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
title_full_unstemmed	Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
title_sort	fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/378a668465b54f94a2144b2dc009b093
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Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

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