Methotrexate Treatment of Newly Diagnosed RA Patients Is Associated With DNA Methylation Differences at Genes Relevant for Disease Pathogenesis and Pharmacological Action

Methotrexate Treatment of Newly Diagnosed RA Patients Is Associated With DNA Methylation Differences at Genes Relevant for Disease Pathogenesis and Pharmacological Action

BackgroundMethotrexate (MTX) is the first line treatment of rheumatoid arthritis (RA), and methylation changes in bulk T cells have been reported after treatment with MTX. We have investigated cell-type specific DNA methylation changes across the genome in naïve and memory CD4+ T cells before and af...

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Autores principales: Kari Guderud, Line H. Sunde, Siri T. Flåm, Marthe T. Mæhlen, Maria D. Mjaavatten, Ellen S. Norli, Ida M. Evenrød, Bettina K. Andreassen, Sören Franzenburg, Andre Franke, Simon Rayner, Kristina Gervin, Benedicte A. Lie
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
Rheumatoid arthritis
T cells
CD4 memory
CD4 naïve
DNA methylation
RRBS
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/378fc971d1b14ca1be320098ff49f2fa
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