Methotrexate Treatment of Newly Diagnosed RA Patients Is Associated With DNA Methylation Differences at Genes Relevant for Disease Pathogenesis and Pharmacological Action

Methotrexate Treatment of Newly Diagnosed RA Patients Is Associated With DNA Methylation Differences at Genes Relevant for Disease Pathogenesis and Pharmacological Action

BackgroundMethotrexate (MTX) is the first line treatment of rheumatoid arthritis (RA), and methylation changes in bulk T cells have been reported after treatment with MTX. We have investigated cell-type specific DNA methylation changes across the genome in naïve and memory CD4+ T cells before and af...

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Bibliographic Details
Main Authors: Kari Guderud, Line H. Sunde, Siri T. Flåm, Marthe T. Mæhlen, Maria D. Mjaavatten, Ellen S. Norli, Ida M. Evenrød, Bettina K. Andreassen, Sören Franzenburg, Andre Franke, Simon Rayner, Kristina Gervin, Benedicte A. Lie
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
Rheumatoid arthritis
T cells
CD4 memory
CD4 naïve
DNA methylation
RRBS
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/378fc971d1b14ca1be320098ff49f2fa
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https://doaj.org/article/378fc971d1b14ca1be320098ff49f2fa

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