Increased formate overflow is a hallmark of oxidative cancer

Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of cancer cells.

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Autores principales:	Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian M. Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou, Alexei Vazquez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3791b6fce2b1446482c02c147ec6dfd2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:3791b6fce2b1446482c02c147ec6dfd22021-12-02T14:41:05ZIncreased formate overflow is a hallmark of oxidative cancer10.1038/s41467-018-03777-w2041-1723https://doaj.org/article/3791b6fce2b1446482c02c147ec6dfd22018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03777-whttps://doaj.org/toc/2041-1723Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of cancer cells.Johannes MeiserAnne SchusterMatthias PietzkeJohan Vande VoordeDimitris AthineosKristell OizelGuillermo Burgos-BarraganNiek WitSandeep DhayadeJennifer P. MortonEmmanuel DornierDavid SumptonGillian M. MackayKaren BlythKetan J. PatelSimone P. NiclouAlexei VazquezNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Johannes Meiser Anne Schuster Matthias Pietzke Johan Vande Voorde Dimitris Athineos Kristell Oizel Guillermo Burgos-Barragan Niek Wit Sandeep Dhayade Jennifer P. Morton Emmanuel Dornier David Sumpton Gillian M. Mackay Karen Blyth Ketan J. Patel Simone P. Niclou Alexei Vazquez Increased formate overflow is a hallmark of oxidative cancer
description	Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of cancer cells.
format	article
author	Johannes Meiser Anne Schuster Matthias Pietzke Johan Vande Voorde Dimitris Athineos Kristell Oizel Guillermo Burgos-Barragan Niek Wit Sandeep Dhayade Jennifer P. Morton Emmanuel Dornier David Sumpton Gillian M. Mackay Karen Blyth Ketan J. Patel Simone P. Niclou Alexei Vazquez
author_facet	Johannes Meiser Anne Schuster Matthias Pietzke Johan Vande Voorde Dimitris Athineos Kristell Oizel Guillermo Burgos-Barragan Niek Wit Sandeep Dhayade Jennifer P. Morton Emmanuel Dornier David Sumpton Gillian M. Mackay Karen Blyth Ketan J. Patel Simone P. Niclou Alexei Vazquez
author_sort	Johannes Meiser
title	Increased formate overflow is a hallmark of oxidative cancer
title_short	Increased formate overflow is a hallmark of oxidative cancer
title_full	Increased formate overflow is a hallmark of oxidative cancer
title_fullStr	Increased formate overflow is a hallmark of oxidative cancer
title_full_unstemmed	Increased formate overflow is a hallmark of oxidative cancer
title_sort	increased formate overflow is a hallmark of oxidative cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3791b6fce2b1446482c02c147ec6dfd2
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_version_	1718389983970066432

Increased formate overflow is a hallmark of oxidative cancer

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