Honey in wound healing: An updated review

Wound healing is a complex process with many interdependent pathophysiological and immunological mediators to restore the cellular integrity of damaged tissue. Cutaneous wound healing is the repair response to a multitude of pathologies induced by trauma, surgery, and burn leading to the restoration...

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Autor principal:	Tashkandi Hanaa
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	wound healing honey multidrug-resistant bacteria antibacterial effects antifungal properties Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3792d205bfa8482a8a13e8a3e241334b
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spelling	oai:doaj.org-article:3792d205bfa8482a8a13e8a3e241334b2021-12-05T14:10:41ZHoney in wound healing: An updated review2391-541210.1515/biol-2021-0084https://doaj.org/article/3792d205bfa8482a8a13e8a3e241334b2021-10-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0084https://doaj.org/toc/2391-5412Wound healing is a complex process with many interdependent pathophysiological and immunological mediators to restore the cellular integrity of damaged tissue. Cutaneous wound healing is the repair response to a multitude of pathologies induced by trauma, surgery, and burn leading to the restoration and functionality of the compromised cells. Many different methods have been employed to treat acute and chronic wounds, such as antimicrobial therapy, as most wounds are susceptible to infection from microbes and are difficult to treat. However, many antimicrobial agents have become ineffective in wound treatment due to the emergence of multiple drug-resistant bacteria, and failures in current wound treatment methods have been widely reported. For this reason, alternative therapies have been sought, one of which is the use of honey as a wound treatment agent. The use of honey has recently gained clinical popularity for possible use in wound treatment and regenerative medicine. With this high demand, a better delivery and application procedure is required, as well as research aiming at its bioactivity. Honey is a safe natural substance, effective in the inhibition of bacterial growth and the treatment of a broad range of wound types, including burns, scratches, diabetic boils (Skin abscesses associated with diabetic), malignancies, leprosy, fistulas, leg ulcers, traumatic boils, cervical and varicose ulcers, amputation, burst abdominal wounds, septic and surgical wounds, cracked nipples, and wounds in the abdominal wall. Honey comprises a wide variety of active compounds, including flavonoids, phenolic acid, organic acids, enzymes, and vitamins, that may act to improve the wound healing process. Tissue-engineered scaffolds have recently attracted a great deal of attention, and various scaffold fabrication techniques are being researched. Some incorporate honey to improve their delivery during wound treatment. Hence, the aim of this review is to summarize recent studies on the wound healing properties of honey.Tashkandi HanaaDe Gruyterarticlewound healinghoneymultidrug-resistant bacteriaantibacterial effectsantifungal propertiesBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 1091-1100 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	wound healing honey multidrug-resistant bacteria antibacterial effects antifungal properties Biology (General) QH301-705.5
spellingShingle	wound healing honey multidrug-resistant bacteria antibacterial effects antifungal properties Biology (General) QH301-705.5 Tashkandi Hanaa Honey in wound healing: An updated review
description	Wound healing is a complex process with many interdependent pathophysiological and immunological mediators to restore the cellular integrity of damaged tissue. Cutaneous wound healing is the repair response to a multitude of pathologies induced by trauma, surgery, and burn leading to the restoration and functionality of the compromised cells. Many different methods have been employed to treat acute and chronic wounds, such as antimicrobial therapy, as most wounds are susceptible to infection from microbes and are difficult to treat. However, many antimicrobial agents have become ineffective in wound treatment due to the emergence of multiple drug-resistant bacteria, and failures in current wound treatment methods have been widely reported. For this reason, alternative therapies have been sought, one of which is the use of honey as a wound treatment agent. The use of honey has recently gained clinical popularity for possible use in wound treatment and regenerative medicine. With this high demand, a better delivery and application procedure is required, as well as research aiming at its bioactivity. Honey is a safe natural substance, effective in the inhibition of bacterial growth and the treatment of a broad range of wound types, including burns, scratches, diabetic boils (Skin abscesses associated with diabetic), malignancies, leprosy, fistulas, leg ulcers, traumatic boils, cervical and varicose ulcers, amputation, burst abdominal wounds, septic and surgical wounds, cracked nipples, and wounds in the abdominal wall. Honey comprises a wide variety of active compounds, including flavonoids, phenolic acid, organic acids, enzymes, and vitamins, that may act to improve the wound healing process. Tissue-engineered scaffolds have recently attracted a great deal of attention, and various scaffold fabrication techniques are being researched. Some incorporate honey to improve their delivery during wound treatment. Hence, the aim of this review is to summarize recent studies on the wound healing properties of honey.
format	article
author	Tashkandi Hanaa
author_facet	Tashkandi Hanaa
author_sort	Tashkandi Hanaa
title	Honey in wound healing: An updated review
title_short	Honey in wound healing: An updated review
title_full	Honey in wound healing: An updated review
title_fullStr	Honey in wound healing: An updated review
title_full_unstemmed	Honey in wound healing: An updated review
title_sort	honey in wound healing: an updated review
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/3792d205bfa8482a8a13e8a3e241334b
work_keys_str_mv	AT tashkandihanaa honeyinwoundhealinganupdatedreview
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Honey in wound healing: An updated review

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