Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.

<h4>Background</h4>Circulating tumor cells (CTCs) have been considered diagnostic and prognostic biomarkers for urothelial cancer. However, the prognostic role of CTCs in bladder cancer (BC) remains controversial. Here, we conducted a meta-analysis to evaluate the prognostic significance...

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Autores principales:	Hui Jiang, Xiujuan Gu, Zhihua Zuo, Gang Tian, Jinbo Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/379377e64f58473986bf926c4983594f
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spelling	oai:doaj.org-article:379377e64f58473986bf926c4983594f2021-12-02T20:15:31ZPrognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.1932-620310.1371/journal.pone.0254433https://doaj.org/article/379377e64f58473986bf926c4983594f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254433https://doaj.org/toc/1932-6203<h4>Background</h4>Circulating tumor cells (CTCs) have been considered diagnostic and prognostic biomarkers for urothelial cancer. However, the prognostic role of CTCs in bladder cancer (BC) remains controversial. Here, we conducted a meta-analysis to evaluate the prognostic significance of CTCs for patients with BC.<h4>Methods</h4>All studies relevant to this topic were searched in the PubMed, Embase, and Web of Science databases. The hazard ratio (HR) and 95% confidence interval (95% CI) were set as effect measures. The outcomes were overall survival (OS), cancer-free survival (CSS), progression-free survival (PFS)/time to progression (TTP), and disease-free survival (DFS)/recurrence-free survival (RFS)/time to first recurrence (TFR). All analyses were conducted in STATA 15.1.<h4>Results</h4>Eleven eligible studies comprising 1,062 patients with BC were included in this meta-analysis. Overall analyses showed that CTC-positive patients had poorer survival (OS: HR 3.88, 95% CI 2.52-5.96, p < 0.001; CSS: HR 3.89, 95% CI 2.15-7.04, p < 0.001) and more aggressive progression (PFS/TTP: HR 5.92, 95% CI 3.75-9.35, p < 0.001; DFS/RFS/TFR: HR 4.57, 95% CI 3.34-6.25, p < 0.001) than CTC-negative patients. Subgroup analyses according to the number of patients, detection method, positivity rate, and follow-up time revealed that the presence of CTCs predicted a high risk of mortality and disease progression in most subgroups.<h4>Conclusion</h4>The meta-analysis confirmed that CTCs are a promising prognostic biomarker of poor survival and aggressive tumor progression for patients with BC.<h4>Prospero registration number</h4>CRD42021224865.Hui JiangXiujuan GuZhihua ZuoGang TianJinbo LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254433 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui Jiang Xiujuan Gu Zhihua Zuo Gang Tian Jinbo Liu Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.
description	<h4>Background</h4>Circulating tumor cells (CTCs) have been considered diagnostic and prognostic biomarkers for urothelial cancer. However, the prognostic role of CTCs in bladder cancer (BC) remains controversial. Here, we conducted a meta-analysis to evaluate the prognostic significance of CTCs for patients with BC.<h4>Methods</h4>All studies relevant to this topic were searched in the PubMed, Embase, and Web of Science databases. The hazard ratio (HR) and 95% confidence interval (95% CI) were set as effect measures. The outcomes were overall survival (OS), cancer-free survival (CSS), progression-free survival (PFS)/time to progression (TTP), and disease-free survival (DFS)/recurrence-free survival (RFS)/time to first recurrence (TFR). All analyses were conducted in STATA 15.1.<h4>Results</h4>Eleven eligible studies comprising 1,062 patients with BC were included in this meta-analysis. Overall analyses showed that CTC-positive patients had poorer survival (OS: HR 3.88, 95% CI 2.52-5.96, p < 0.001; CSS: HR 3.89, 95% CI 2.15-7.04, p < 0.001) and more aggressive progression (PFS/TTP: HR 5.92, 95% CI 3.75-9.35, p < 0.001; DFS/RFS/TFR: HR 4.57, 95% CI 3.34-6.25, p < 0.001) than CTC-negative patients. Subgroup analyses according to the number of patients, detection method, positivity rate, and follow-up time revealed that the presence of CTCs predicted a high risk of mortality and disease progression in most subgroups.<h4>Conclusion</h4>The meta-analysis confirmed that CTCs are a promising prognostic biomarker of poor survival and aggressive tumor progression for patients with BC.<h4>Prospero registration number</h4>CRD42021224865.
format	article
author	Hui Jiang Xiujuan Gu Zhihua Zuo Gang Tian Jinbo Liu
author_facet	Hui Jiang Xiujuan Gu Zhihua Zuo Gang Tian Jinbo Liu
author_sort	Hui Jiang
title	Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.
title_short	Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.
title_full	Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.
title_fullStr	Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.
title_full_unstemmed	Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.
title_sort	prognostic value of circulating tumor cells in patients with bladder cancer: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/379377e64f58473986bf926c4983594f
work_keys_str_mv	AT huijiang prognosticvalueofcirculatingtumorcellsinpatientswithbladdercancerametaanalysis AT xiujuangu prognosticvalueofcirculatingtumorcellsinpatientswithbladdercancerametaanalysis AT zhihuazuo prognosticvalueofcirculatingtumorcellsinpatientswithbladdercancerametaanalysis AT gangtian prognosticvalueofcirculatingtumorcellsinpatientswithbladdercancerametaanalysis AT jinboliu prognosticvalueofcirculatingtumorcellsinpatientswithbladdercancerametaanalysis
_version_	1718374575513796608

Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.

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