Adequacy of Lymph Node Staging in Colorectal Cancer: Analysis of 250 Patients and Analytical Literature Review

Background The extent of lymph node involvement is the most important prognostic factor in resected locoregional colorectal cancer. Currently, examination of at least 12 lymph nodes is recommended for adequate colorectal cancer staging. Objectives The present study aimed to evaluate the adequac...

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Autores principales:	Leila Ghahramani, Samira Razzaghi, Mohammad Mohammadianpanah, Saeedeh Pourahmad
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2013
Materias:	colorectal cancer colon rectum lymph node staging surgery dissection Medicine R
Acceso en línea:	https://doaj.org/article/3795e5fa87bf41e69d44d50ebea9a881
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spelling	oai:doaj.org-article:3795e5fa87bf41e69d44d50ebea9a8812021-11-14T06:43:18ZAdequacy of Lymph Node Staging in Colorectal Cancer: Analysis of 250 Patients and Analytical Literature Review2783-243010.17795/acr-11495https://doaj.org/article/3795e5fa87bf41e69d44d50ebea9a8812013-06-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45443_3c4de96194397a74bf67a136d63519be.pdfhttps://doaj.org/toc/2783-2430Background The extent of lymph node involvement is the most important prognostic factor in resected locoregional colorectal cancer. Currently, examination of at least 12 lymph nodes is recommended for adequate colorectal cancer staging. Objectives The present study aimed to evaluate the adequacy of lymph node staging in 250 patients with colorectal cancer and analytical literature review. Patients and Methods Two hundred fifty patients with histologically proven locoregional invasive colorectal adenocarcinoma from 2005 to 2011 were included. All patients were treated by standard surgical resection for their disease. Twenty-three patients with rectal cancer received neoadjuvant treatment. All potential tumor, patient and treatment variables were evaluated for their impact on the average total number of lymph node examined. Results In this study, 147 men and 103 women with a median age of 54 (range 23-84) years were included. The median total number of lymph nodes examined was 7 (mean 9.35). Sixty-nine patients (27.6%) had adequate (≥ 12) lymph nodes examination, and twenty patients (8%) had no nodes examined. In univariate analysis, younger age, colon primary site, larger tumor size, the presence of lymphatic vascular invasion, the lack of neoadjuvant treatments, individual surgeon B and Hospital B were more associated with the average total number of lymph node examined. Conclusion This study indicates that only less than a third of patients with colorectal cancer underwent adequate lymph nodes examination. Further investigation using careful pathologic reviewing of specimens with inadequate lymph node examined is suggested for differentiating true inadequate lymph node dissection from inadequate lymph node detection.Leila GhahramaniSamira RazzaghiMohammad MohammadianpanahSaeedeh PourahmadShiraz University of Medical Sciencesarticlecolorectal cancercolonrectumlymph node stagingsurgerydissectionMedicineRENIranian Journal of Colorectal Research, Vol 1, Iss 1, Pp 3-1 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer colon rectum lymph node staging surgery dissection Medicine R
spellingShingle	colorectal cancer colon rectum lymph node staging surgery dissection Medicine R Leila Ghahramani Samira Razzaghi Mohammad Mohammadianpanah Saeedeh Pourahmad Adequacy of Lymph Node Staging in Colorectal Cancer: Analysis of 250 Patients and Analytical Literature Review
description	Background The extent of lymph node involvement is the most important prognostic factor in resected locoregional colorectal cancer. Currently, examination of at least 12 lymph nodes is recommended for adequate colorectal cancer staging. Objectives The present study aimed to evaluate the adequacy of lymph node staging in 250 patients with colorectal cancer and analytical literature review. Patients and Methods Two hundred fifty patients with histologically proven locoregional invasive colorectal adenocarcinoma from 2005 to 2011 were included. All patients were treated by standard surgical resection for their disease. Twenty-three patients with rectal cancer received neoadjuvant treatment. All potential tumor, patient and treatment variables were evaluated for their impact on the average total number of lymph node examined. Results In this study, 147 men and 103 women with a median age of 54 (range 23-84) years were included. The median total number of lymph nodes examined was 7 (mean 9.35). Sixty-nine patients (27.6%) had adequate (≥ 12) lymph nodes examination, and twenty patients (8%) had no nodes examined. In univariate analysis, younger age, colon primary site, larger tumor size, the presence of lymphatic vascular invasion, the lack of neoadjuvant treatments, individual surgeon B and Hospital B were more associated with the average total number of lymph node examined. Conclusion This study indicates that only less than a third of patients with colorectal cancer underwent adequate lymph nodes examination. Further investigation using careful pathologic reviewing of specimens with inadequate lymph node examined is suggested for differentiating true inadequate lymph node dissection from inadequate lymph node detection.
format	article
author	Leila Ghahramani Samira Razzaghi Mohammad Mohammadianpanah Saeedeh Pourahmad
author_facet	Leila Ghahramani Samira Razzaghi Mohammad Mohammadianpanah Saeedeh Pourahmad
author_sort	Leila Ghahramani
title	Adequacy of Lymph Node Staging in Colorectal Cancer: Analysis of 250 Patients and Analytical Literature Review
title_short	Adequacy of Lymph Node Staging in Colorectal Cancer: Analysis of 250 Patients and Analytical Literature Review
title_full	Adequacy of Lymph Node Staging in Colorectal Cancer: Analysis of 250 Patients and Analytical Literature Review
title_fullStr	Adequacy of Lymph Node Staging in Colorectal Cancer: Analysis of 250 Patients and Analytical Literature Review
title_full_unstemmed	Adequacy of Lymph Node Staging in Colorectal Cancer: Analysis of 250 Patients and Analytical Literature Review
title_sort	adequacy of lymph node staging in colorectal cancer: analysis of 250 patients and analytical literature review
publisher	Shiraz University of Medical Sciences
publishDate	2013
url	https://doaj.org/article/3795e5fa87bf41e69d44d50ebea9a881
work_keys_str_mv	AT leilaghahramani adequacyoflymphnodestagingincolorectalcanceranalysisof250patientsandanalyticalliteraturereview AT samirarazzaghi adequacyoflymphnodestagingincolorectalcanceranalysisof250patientsandanalyticalliteraturereview AT mohammadmohammadianpanah adequacyoflymphnodestagingincolorectalcanceranalysisof250patientsandanalyticalliteraturereview AT saeedehpourahmad adequacyoflymphnodestagingincolorectalcanceranalysisof250patientsandanalyticalliteraturereview
_version_	1718429825495990272

Adequacy of Lymph Node Staging in Colorectal Cancer: Analysis of 250 Patients and Analytical Literature Review

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