Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation

Disseminated intravascular coagulation (DIC) is a severe condition characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. In the last years, it represents one of the most frequent consequences of coronavirus disease 2019 (COVID-19). The path...

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Autores principales:	Ramona D’Amico, Francesco Monaco, Rosalba Siracusa, Marika Cordaro, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Daniela Impellizzeri, Tiziana Genovese
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	disseminated intravascular coagulation sepsis coagulation inflammation ultramicronized palmitoylethanolamide Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/3796839d32104142851817fcaddfb37c
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spelling	oai:doaj.org-article:3796839d32104142851817fcaddfb37c2021-11-11T16:51:48ZUltramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation10.3390/ijms2221113881422-00671661-6596https://doaj.org/article/3796839d32104142851817fcaddfb37c2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11388https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Disseminated intravascular coagulation (DIC) is a severe condition characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. In the last years, it represents one of the most frequent consequences of coronavirus disease 2019 (COVID-19). The pathogenesis of DIC is complex, with cross-talk between the coagulant and inflammatory pathways. The objective of this study is to investigate the anti-inflammatory action of ultramicronized palmitoylethanolamide (um-PEA) in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by continual infusion of LPS (30 mg/kg) for 4 h through the tail vein. Um-PEA (30 mg/kg) was given orally 30 min before and 1 h after the start of intravenous infusion of LPS. Results showed that um-PEA reduced alteration of coagulation markers, as well as proinflammatory cytokine release in plasma and lung samples, induced by LPS infusion. Furthermore, um-PEA also has the effect of preventing the formation of fibrin deposition and lung damage. Moreover, um-PEA was able to reduce the number of mast cells (MCs) and the release of its serine proteases, which are also necessary for SARS-CoV-2 infection. These results suggest that um-PEA could be considered as a potential therapeutic approach in the management of DIC and in clinical implications associated to coagulopathy and lung dysfunction, such as COVID-19.Ramona D’AmicoFrancesco MonacoRosalba SiracusaMarika CordaroRoberta FuscoAlessio Filippo PeritoreEnrico GugliandoloRosalia CrupiSalvatore CuzzocreaRosanna Di PaolaDaniela ImpellizzeriTiziana GenoveseMDPI AGarticledisseminated intravascular coagulationsepsiscoagulationinflammationultramicronized palmitoylethanolamideBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11388, p 11388 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	disseminated intravascular coagulation sepsis coagulation inflammation ultramicronized palmitoylethanolamide Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	disseminated intravascular coagulation sepsis coagulation inflammation ultramicronized palmitoylethanolamide Biology (General) QH301-705.5 Chemistry QD1-999 Ramona D’Amico Francesco Monaco Rosalba Siracusa Marika Cordaro Roberta Fusco Alessio Filippo Peritore Enrico Gugliandolo Rosalia Crupi Salvatore Cuzzocrea Rosanna Di Paola Daniela Impellizzeri Tiziana Genovese Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation
description	Disseminated intravascular coagulation (DIC) is a severe condition characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. In the last years, it represents one of the most frequent consequences of coronavirus disease 2019 (COVID-19). The pathogenesis of DIC is complex, with cross-talk between the coagulant and inflammatory pathways. The objective of this study is to investigate the anti-inflammatory action of ultramicronized palmitoylethanolamide (um-PEA) in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by continual infusion of LPS (30 mg/kg) for 4 h through the tail vein. Um-PEA (30 mg/kg) was given orally 30 min before and 1 h after the start of intravenous infusion of LPS. Results showed that um-PEA reduced alteration of coagulation markers, as well as proinflammatory cytokine release in plasma and lung samples, induced by LPS infusion. Furthermore, um-PEA also has the effect of preventing the formation of fibrin deposition and lung damage. Moreover, um-PEA was able to reduce the number of mast cells (MCs) and the release of its serine proteases, which are also necessary for SARS-CoV-2 infection. These results suggest that um-PEA could be considered as a potential therapeutic approach in the management of DIC and in clinical implications associated to coagulopathy and lung dysfunction, such as COVID-19.
format	article
author	Ramona D’Amico Francesco Monaco Rosalba Siracusa Marika Cordaro Roberta Fusco Alessio Filippo Peritore Enrico Gugliandolo Rosalia Crupi Salvatore Cuzzocrea Rosanna Di Paola Daniela Impellizzeri Tiziana Genovese
author_facet	Ramona D’Amico Francesco Monaco Rosalba Siracusa Marika Cordaro Roberta Fusco Alessio Filippo Peritore Enrico Gugliandolo Rosalia Crupi Salvatore Cuzzocrea Rosanna Di Paola Daniela Impellizzeri Tiziana Genovese
author_sort	Ramona D’Amico
title	Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation
title_short	Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation
title_full	Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation
title_fullStr	Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation
title_full_unstemmed	Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation
title_sort	ultramicronized palmitoylethanolamide in the management of sepsis-induced coagulopathy and disseminated intravascular coagulation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3796839d32104142851817fcaddfb37c
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Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation

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