Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles

Abstract Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti...

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Autores principales:	Tamoghna Mandal, Michaela Beck, Nicole Kirsten, Mika Lindén, Christian Buske
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3797cf968779482ab6d8630918678c02
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spelling	oai:doaj.org-article:3797cf968779482ab6d8630918678c022021-12-02T11:40:45ZTargeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles10.1038/s41598-017-18932-42045-2322https://doaj.org/article/3797cf968779482ab6d8630918678c022018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-18932-4https://doaj.org/toc/2045-2322Abstract Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti-B220 antibody and loaded with the anthracycline daunorubicin are efficiently incorporated into murine B220-positive AML LSCs and preferentially kill these cells in comparison to B220-negative AML LSCs in vitro. Furthermore, short – term treatment of the AML LSCs with these MSNs before transplant significantly delayed leukemia development in recipient mice. These data demonstrate that targeting of AML LSCs can be improved by using functionalized and antigen directed MSNs as carriers for anti-leukemic drugs.Tamoghna MandalMichaela BeckNicole KirstenMika LindénChristian BuskeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tamoghna Mandal Michaela Beck Nicole Kirsten Mika Lindén Christian Buske Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
description	Abstract Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti-B220 antibody and loaded with the anthracycline daunorubicin are efficiently incorporated into murine B220-positive AML LSCs and preferentially kill these cells in comparison to B220-negative AML LSCs in vitro. Furthermore, short – term treatment of the AML LSCs with these MSNs before transplant significantly delayed leukemia development in recipient mice. These data demonstrate that targeting of AML LSCs can be improved by using functionalized and antigen directed MSNs as carriers for anti-leukemic drugs.
format	article
author	Tamoghna Mandal Michaela Beck Nicole Kirsten Mika Lindén Christian Buske
author_facet	Tamoghna Mandal Michaela Beck Nicole Kirsten Mika Lindén Christian Buske
author_sort	Tamoghna Mandal
title	Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_short	Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_full	Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_fullStr	Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_full_unstemmed	Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_sort	targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3797cf968779482ab6d8630918678c02
work_keys_str_mv	AT tamoghnamandal targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles AT michaelabeck targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles AT nicolekirsten targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles AT mikalinden targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles AT christianbuske targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles
_version_	1718395511110631424

Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles

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