Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats

Abstract Mechanisms involved in the acute responses to renal denervation (RDN) have yet to be fully understood. We assessed urinary volume, autonomic control and aorta vascular reactivity after acute RDN. Male normotensive Wistar rats and spontaneously hypertensive rats (SHR) were divided into normo...

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Autores principales:	Nathalia Juocys Dias Moreira, Fernando dos Santos, Edson Dias Moreira, Daniela Farah, Leandro Eziquiel de Souza, Maikon Barbosa da Silva, Ivana Cinthya Moraes-Silva, Gisele Silvério Lincevicius, Elia Garcia Caldini, Maria Cláudia Costa Irigoyen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37994b54d92641c495feb16cf7abeadc
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spelling	oai:doaj.org-article:37994b54d92641c495feb16cf7abeadc2021-12-02T12:33:14ZAcute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats10.1038/s41598-020-78674-82045-2322https://doaj.org/article/37994b54d92641c495feb16cf7abeadc2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78674-8https://doaj.org/toc/2045-2322Abstract Mechanisms involved in the acute responses to renal denervation (RDN) have yet to be fully understood. We assessed urinary volume, autonomic control and aorta vascular reactivity after acute RDN. Male normotensive Wistar rats and spontaneously hypertensive rats (SHR) were divided into normotensive + RDN (ND) or sham surgery (NS), and hypertensive + RDN (HD) or sham surgery (HS). Metabolic parameters and hemodynamic measurements were recorded 72h and 4 days after intervention, respectively. Aortic rings were studied 7 days post RDN in an isometric myograph. Concentration–response curves to phenylephrine, sodium nitroprusside and acetylcholine (10–10–10−5 M) were performed. Two-way ANOVA was used for group comparisons and differences reported when p < 0.05. Results are presented as mean ± SEM. Urinary volume was 112% higher in HD vs. HS (HS = 14.94 ± 2.5 mL; HD = 31.69 ± 2.2 mL) and remained unchanged in normotensive rats. Systolic BP was lower in HD rats (HS = 201 ± 12 vs. HD = 172 ± 3 mmHg) without changes in normotensive group. HD group showed increased HF and LF modulation (HS = 5.8 ± 0.7 ms2 vs. HD = 13.4 ± 1.4 ms2; HS = 3.5 ± 0.7 ms2 vs. HD = 10.5 ± 1.7 ms2, respectively). RDN normalized vascular reactivity in HD rats and increased phenylephrine response in ND rats. Acute fall in BP induced by RDN is associated with increased urinary volume, which in turn may also have contributed to functional changes of the aorta.Nathalia Juocys Dias MoreiraFernando dos SantosEdson Dias MoreiraDaniela FarahLeandro Eziquiel de SouzaMaikon Barbosa da SilvaIvana Cinthya Moraes-SilvaGisele Silvério LinceviciusElia Garcia CaldiniMaria Cláudia Costa IrigoyenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nathalia Juocys Dias Moreira Fernando dos Santos Edson Dias Moreira Daniela Farah Leandro Eziquiel de Souza Maikon Barbosa da Silva Ivana Cinthya Moraes-Silva Gisele Silvério Lincevicius Elia Garcia Caldini Maria Cláudia Costa Irigoyen Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats
description	Abstract Mechanisms involved in the acute responses to renal denervation (RDN) have yet to be fully understood. We assessed urinary volume, autonomic control and aorta vascular reactivity after acute RDN. Male normotensive Wistar rats and spontaneously hypertensive rats (SHR) were divided into normotensive + RDN (ND) or sham surgery (NS), and hypertensive + RDN (HD) or sham surgery (HS). Metabolic parameters and hemodynamic measurements were recorded 72h and 4 days after intervention, respectively. Aortic rings were studied 7 days post RDN in an isometric myograph. Concentration–response curves to phenylephrine, sodium nitroprusside and acetylcholine (10–10–10−5 M) were performed. Two-way ANOVA was used for group comparisons and differences reported when p < 0.05. Results are presented as mean ± SEM. Urinary volume was 112% higher in HD vs. HS (HS = 14.94 ± 2.5 mL; HD = 31.69 ± 2.2 mL) and remained unchanged in normotensive rats. Systolic BP was lower in HD rats (HS = 201 ± 12 vs. HD = 172 ± 3 mmHg) without changes in normotensive group. HD group showed increased HF and LF modulation (HS = 5.8 ± 0.7 ms2 vs. HD = 13.4 ± 1.4 ms2; HS = 3.5 ± 0.7 ms2 vs. HD = 10.5 ± 1.7 ms2, respectively). RDN normalized vascular reactivity in HD rats and increased phenylephrine response in ND rats. Acute fall in BP induced by RDN is associated with increased urinary volume, which in turn may also have contributed to functional changes of the aorta.
format	article
author	Nathalia Juocys Dias Moreira Fernando dos Santos Edson Dias Moreira Daniela Farah Leandro Eziquiel de Souza Maikon Barbosa da Silva Ivana Cinthya Moraes-Silva Gisele Silvério Lincevicius Elia Garcia Caldini Maria Cláudia Costa Irigoyen
author_facet	Nathalia Juocys Dias Moreira Fernando dos Santos Edson Dias Moreira Daniela Farah Leandro Eziquiel de Souza Maikon Barbosa da Silva Ivana Cinthya Moraes-Silva Gisele Silvério Lincevicius Elia Garcia Caldini Maria Cláudia Costa Irigoyen
author_sort	Nathalia Juocys Dias Moreira
title	Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats
title_short	Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats
title_full	Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats
title_fullStr	Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats
title_full_unstemmed	Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats
title_sort	acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/37994b54d92641c495feb16cf7abeadc
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Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats

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