Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.

<h4>Background</h4>Immune priming has been shown to occur in a wide array of invertebrate taxa, with individuals exposed to a pathogen showing increased protection upon subsequent exposure. However, the mechanisms underlying immune priming are poorly understood. The antiviral RNAi respon...

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Autores principales:	Ben Longdon, Chuan Cao, Julien Martinez, Francis M Jiggins
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/379a1ce9668c4e6687e52408ac8615ce
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spelling	oai:doaj.org-article:379a1ce9668c4e6687e52408ac8615ce2021-11-18T08:55:47ZPrevious exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.1932-620310.1371/journal.pone.0073833https://doaj.org/article/379a1ce9668c4e6687e52408ac8615ce2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040086/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Immune priming has been shown to occur in a wide array of invertebrate taxa, with individuals exposed to a pathogen showing increased protection upon subsequent exposure. However, the mechanisms underlying immune priming are poorly understood. The antiviral RNAi response in Drosophila melanogaster is an ideal candidate for providing a specific and acquired response to subsequent infection. We exposed D. melanogaster to two challenges of a virus known to produce an antiviral RNAi response, to examine whether any protective effects of prior exposure on survival were observed.<h4>Results</h4>In this experiment we found no evidence that prior exposure to Drosophila C Virus (DCV) protects flies from a subsequent lethal challenge, with almost identical levels of mortality in flies previously exposed to DCV or a control.<h4>Conclusions</h4>Our results confirm the finding that 'acquired' immune responses are not ubiquitous across all invertebrate-pathogen interactions. We discuss why we may have observed no effect in this study, with focus on the mechanistic basis of the RNAi pathway.Ben LongdonChuan CaoJulien MartinezFrancis M JigginsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73833 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ben Longdon Chuan Cao Julien Martinez Francis M Jiggins Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.
description	<h4>Background</h4>Immune priming has been shown to occur in a wide array of invertebrate taxa, with individuals exposed to a pathogen showing increased protection upon subsequent exposure. However, the mechanisms underlying immune priming are poorly understood. The antiviral RNAi response in Drosophila melanogaster is an ideal candidate for providing a specific and acquired response to subsequent infection. We exposed D. melanogaster to two challenges of a virus known to produce an antiviral RNAi response, to examine whether any protective effects of prior exposure on survival were observed.<h4>Results</h4>In this experiment we found no evidence that prior exposure to Drosophila C Virus (DCV) protects flies from a subsequent lethal challenge, with almost identical levels of mortality in flies previously exposed to DCV or a control.<h4>Conclusions</h4>Our results confirm the finding that 'acquired' immune responses are not ubiquitous across all invertebrate-pathogen interactions. We discuss why we may have observed no effect in this study, with focus on the mechanistic basis of the RNAi pathway.
format	article
author	Ben Longdon Chuan Cao Julien Martinez Francis M Jiggins
author_facet	Ben Longdon Chuan Cao Julien Martinez Francis M Jiggins
author_sort	Ben Longdon
title	Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.
title_short	Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.
title_full	Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.
title_fullStr	Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.
title_full_unstemmed	Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.
title_sort	previous exposure to an rna virus does not protect against subsequent infection in drosophila melanogaster.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/379a1ce9668c4e6687e52408ac8615ce
work_keys_str_mv	AT benlongdon previousexposuretoanrnavirusdoesnotprotectagainstsubsequentinfectionindrosophilamelanogaster AT chuancao previousexposuretoanrnavirusdoesnotprotectagainstsubsequentinfectionindrosophilamelanogaster AT julienmartinez previousexposuretoanrnavirusdoesnotprotectagainstsubsequentinfectionindrosophilamelanogaster AT francismjiggins previousexposuretoanrnavirusdoesnotprotectagainstsubsequentinfectionindrosophilamelanogaster
_version_	1718421134245888000

Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.

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