Precision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani

Precision medicine and precision global health in visceral leishmaniasis (VL) have not yet been described and could take into account how all known determinants improve diagnostics and treatment for the individual patient. Precision public health would lead to the right intervention in each VL endem...

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Autor principal:	Eduard E. Zijlstra
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	precision medicine and public heath visceral leishmaniasis diagnosis treatment PKDL asymptomatic infection Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/379b6f9beb104eb79b65e6f37d4d87fc
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spelling	oai:doaj.org-article:379b6f9beb104eb79b65e6f37d4d87fc2021-11-09T06:45:48ZPrecision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani2235-298810.3389/fcimb.2021.707619https://doaj.org/article/379b6f9beb104eb79b65e6f37d4d87fc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.707619/fullhttps://doaj.org/toc/2235-2988Precision medicine and precision global health in visceral leishmaniasis (VL) have not yet been described and could take into account how all known determinants improve diagnostics and treatment for the individual patient. Precision public health would lead to the right intervention in each VL endemic population for control, based on relevant population-based data, vector exposures, reservoirs, socio-economic factors and other determinants. In anthroponotic VL caused by L. donovani, precision may currently be targeted to the regional level in nosogeographic entities that are defined by the interplay of the circulating parasite, the reservoir and the sand fly vector. From this 5 major priorities arise: diagnosis, treatment, PKDL, asymptomatic infection and transmission. These 5 priorities share the immune responses of infection with L. donovani as an important final common pathway, for which innovative new genomic and non-genomic tools in various disciplines have become available that provide new insights in clinical management and in control. From this, further precision may be defined for groups (e.g. children, women, pregnancy, HIV-VL co-infection), and eventually targeted to the individual level.Eduard E. ZijlstraFrontiers Media S.A.articleprecision medicine and public heathvisceral leishmaniasisdiagnosistreatmentPKDLasymptomatic infectionMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	precision medicine and public heath visceral leishmaniasis diagnosis treatment PKDL asymptomatic infection Microbiology QR1-502
spellingShingle	precision medicine and public heath visceral leishmaniasis diagnosis treatment PKDL asymptomatic infection Microbiology QR1-502 Eduard E. Zijlstra Precision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani
description	Precision medicine and precision global health in visceral leishmaniasis (VL) have not yet been described and could take into account how all known determinants improve diagnostics and treatment for the individual patient. Precision public health would lead to the right intervention in each VL endemic population for control, based on relevant population-based data, vector exposures, reservoirs, socio-economic factors and other determinants. In anthroponotic VL caused by L. donovani, precision may currently be targeted to the regional level in nosogeographic entities that are defined by the interplay of the circulating parasite, the reservoir and the sand fly vector. From this 5 major priorities arise: diagnosis, treatment, PKDL, asymptomatic infection and transmission. These 5 priorities share the immune responses of infection with L. donovani as an important final common pathway, for which innovative new genomic and non-genomic tools in various disciplines have become available that provide new insights in clinical management and in control. From this, further precision may be defined for groups (e.g. children, women, pregnancy, HIV-VL co-infection), and eventually targeted to the individual level.
format	article
author	Eduard E. Zijlstra
author_facet	Eduard E. Zijlstra
author_sort	Eduard E. Zijlstra
title	Precision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani
title_short	Precision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani
title_full	Precision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani
title_fullStr	Precision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani
title_full_unstemmed	Precision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani
title_sort	precision medicine in control of visceral leishmaniasis caused by l. donovani
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/379b6f9beb104eb79b65e6f37d4d87fc
work_keys_str_mv	AT eduardezijlstra precisionmedicineincontrolofvisceralleishmaniasiscausedbyldonovani
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Precision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani

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