A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities
Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for exploring and understanding effective drug combinations....
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Nature Portfolio
2020
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oai:doaj.org-article:379bf84492484b43b2eac920159ae2732021-12-02T14:59:27ZA cancer drug atlas enables synergistic targeting of independent drug vulnerabilities10.1038/s41467-020-16735-22041-1723https://doaj.org/article/379bf84492484b43b2eac920159ae2732020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16735-2https://doaj.org/toc/2041-1723Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for exploring and understanding effective drug combinations.Ravi S. NarayanPiet MolenaarJian TengFleur M. G. CornelissenIrene RoelofsRenee MenezesRogier DikTonny LagerweijYoran BroersmaNaomi PetersenJhon Alexander Marin SotoEelke BrandsPhilip van KuikenMaria C. LeccaKristiaan J. LenosSjors G. J. G. In ‘t VeldWessel van WieringenFrederick F. LangErik SulmanRoel VerhaakBrigitta G. BaumertLucas J. A. StalpersLouis VermeulenColin WattsDavid BaileyBen J. SlotmanRogier VersteegDavid NoskePeter SminiaBakhos A. TannousTom WurdingerJan KosterBart A. WestermanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ravi S. Narayan Piet Molenaar Jian Teng Fleur M. G. Cornelissen Irene Roelofs Renee Menezes Rogier Dik Tonny Lagerweij Yoran Broersma Naomi Petersen Jhon Alexander Marin Soto Eelke Brands Philip van Kuiken Maria C. Lecca Kristiaan J. Lenos Sjors G. J. G. In ‘t Veld Wessel van Wieringen Frederick F. Lang Erik Sulman Roel Verhaak Brigitta G. Baumert Lucas J. A. Stalpers Louis Vermeulen Colin Watts David Bailey Ben J. Slotman Rogier Versteeg David Noske Peter Sminia Bakhos A. Tannous Tom Wurdinger Jan Koster Bart A. Westerman A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities |
| description |
Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for exploring and understanding effective drug combinations. |
| format |
article |
| author |
Ravi S. Narayan Piet Molenaar Jian Teng Fleur M. G. Cornelissen Irene Roelofs Renee Menezes Rogier Dik Tonny Lagerweij Yoran Broersma Naomi Petersen Jhon Alexander Marin Soto Eelke Brands Philip van Kuiken Maria C. Lecca Kristiaan J. Lenos Sjors G. J. G. In ‘t Veld Wessel van Wieringen Frederick F. Lang Erik Sulman Roel Verhaak Brigitta G. Baumert Lucas J. A. Stalpers Louis Vermeulen Colin Watts David Bailey Ben J. Slotman Rogier Versteeg David Noske Peter Sminia Bakhos A. Tannous Tom Wurdinger Jan Koster Bart A. Westerman |
| author_facet |
Ravi S. Narayan Piet Molenaar Jian Teng Fleur M. G. Cornelissen Irene Roelofs Renee Menezes Rogier Dik Tonny Lagerweij Yoran Broersma Naomi Petersen Jhon Alexander Marin Soto Eelke Brands Philip van Kuiken Maria C. Lecca Kristiaan J. Lenos Sjors G. J. G. In ‘t Veld Wessel van Wieringen Frederick F. Lang Erik Sulman Roel Verhaak Brigitta G. Baumert Lucas J. A. Stalpers Louis Vermeulen Colin Watts David Bailey Ben J. Slotman Rogier Versteeg David Noske Peter Sminia Bakhos A. Tannous Tom Wurdinger Jan Koster Bart A. Westerman |
| author_sort |
Ravi S. Narayan |
| title |
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities |
| title_short |
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities |
| title_full |
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities |
| title_fullStr |
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities |
| title_full_unstemmed |
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities |
| title_sort |
cancer drug atlas enables synergistic targeting of independent drug vulnerabilities |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/379bf84492484b43b2eac920159ae273 |
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