The relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea

Abstract Insecticide resistance across sub-Saharan Africa may impact the continued effectiveness of malaria vector control. We investigated the association between carbamate and pyrethroid resistance with Anopheles gambiae s.l. parity, Plasmodium falciparum infection, and molecular insecticide resis...

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Autores principales:	Emma Collins, Natasha M. Vaselli, Moussa Sylla, Abdoul H. Beavogui, James Orsborne, Gena Lawrence, Ryan E. Wiegand, Seth R. Irish, Thomas Walker, Louisa A. Messenger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37a5e148709c45dea78ce44bde340433
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spelling	oai:doaj.org-article:37a5e148709c45dea78ce44bde3404332021-12-02T15:09:34ZThe relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea10.1038/s41598-019-45261-52045-2322https://doaj.org/article/37a5e148709c45dea78ce44bde3404332019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45261-5https://doaj.org/toc/2045-2322Abstract Insecticide resistance across sub-Saharan Africa may impact the continued effectiveness of malaria vector control. We investigated the association between carbamate and pyrethroid resistance with Anopheles gambiae s.l. parity, Plasmodium falciparum infection, and molecular insecticide resistance mechanisms in Guinea. Pyrethroid resistance was intense, with field populations surviving ten times the insecticidal concentration required to kill susceptible individuals. The L1014F kdr-N1575Y haplotype and I1527T mutation were significantly associated with mosquito survival following permethrin exposure (Prevalence Ratio; PR = 1.92, CI = 1.09–3.37 and PR = 2.80, CI = 1.03–7.64, respectively). Partial restoration of pyrethroid susceptibility following synergist pre-exposure suggests a role for mixed-function oxidases. Carbamate resistance was lower and significantly associated with the G119S Ace-1 mutation. Oocyst rates were 6.8% and 4.2% among resistant and susceptible mosquitoes, respectively; survivors of bendiocarb exposure were significantly more likely to be infected. Pyrethroid resistant mosquitoes had significantly lower parity rates than their susceptible counterparts (PR = 1.15, CI = 1.10–1.21). Our findings emphasize the need for additional studies directly assessing the influence of insecticide resistance on mosquito fitness.Emma CollinsNatasha M. VaselliMoussa SyllaAbdoul H. BeavoguiJames OrsborneGena LawrenceRyan E. WiegandSeth R. IrishThomas WalkerLouisa A. MessengerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emma Collins Natasha M. Vaselli Moussa Sylla Abdoul H. Beavogui James Orsborne Gena Lawrence Ryan E. Wiegand Seth R. Irish Thomas Walker Louisa A. Messenger The relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea
description	Abstract Insecticide resistance across sub-Saharan Africa may impact the continued effectiveness of malaria vector control. We investigated the association between carbamate and pyrethroid resistance with Anopheles gambiae s.l. parity, Plasmodium falciparum infection, and molecular insecticide resistance mechanisms in Guinea. Pyrethroid resistance was intense, with field populations surviving ten times the insecticidal concentration required to kill susceptible individuals. The L1014F kdr-N1575Y haplotype and I1527T mutation were significantly associated with mosquito survival following permethrin exposure (Prevalence Ratio; PR = 1.92, CI = 1.09–3.37 and PR = 2.80, CI = 1.03–7.64, respectively). Partial restoration of pyrethroid susceptibility following synergist pre-exposure suggests a role for mixed-function oxidases. Carbamate resistance was lower and significantly associated with the G119S Ace-1 mutation. Oocyst rates were 6.8% and 4.2% among resistant and susceptible mosquitoes, respectively; survivors of bendiocarb exposure were significantly more likely to be infected. Pyrethroid resistant mosquitoes had significantly lower parity rates than their susceptible counterparts (PR = 1.15, CI = 1.10–1.21). Our findings emphasize the need for additional studies directly assessing the influence of insecticide resistance on mosquito fitness.
format	article
author	Emma Collins Natasha M. Vaselli Moussa Sylla Abdoul H. Beavogui James Orsborne Gena Lawrence Ryan E. Wiegand Seth R. Irish Thomas Walker Louisa A. Messenger
author_facet	Emma Collins Natasha M. Vaselli Moussa Sylla Abdoul H. Beavogui James Orsborne Gena Lawrence Ryan E. Wiegand Seth R. Irish Thomas Walker Louisa A. Messenger
author_sort	Emma Collins
title	The relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea
title_short	The relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea
title_full	The relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea
title_fullStr	The relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea
title_full_unstemmed	The relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea
title_sort	relationship between insecticide resistance, mosquito age and malaria prevalence in anopheles gambiae s.l. from guinea
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/37a5e148709c45dea78ce44bde340433
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The relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea

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