Detecting and phasing minor single-nucleotide variants from long-read sequencing data

Cellular genetic heterogeneity is common across biological conditions, yet application of long-read sequencing to this subject is limited by error rates. Here, the authors present iGDA, a tool for detection and phasing of minor variants from long-read sequencing data, allowing accurate reconstructio...

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Autores principales:	Zhixing Feng, Jose C. Clemente, Brandon Wong, Eric E. Schadt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37aa516a22e74b34bed4e369ee1e4b98
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spelling	oai:doaj.org-article:37aa516a22e74b34bed4e369ee1e4b982021-12-02T14:49:16ZDetecting and phasing minor single-nucleotide variants from long-read sequencing data10.1038/s41467-021-23289-42041-1723https://doaj.org/article/37aa516a22e74b34bed4e369ee1e4b982021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23289-4https://doaj.org/toc/2041-1723Cellular genetic heterogeneity is common across biological conditions, yet application of long-read sequencing to this subject is limited by error rates. Here, the authors present iGDA, a tool for detection and phasing of minor variants from long-read sequencing data, allowing accurate reconstruction of haplotypes.Zhixing FengJose C. ClementeBrandon WongEric E. SchadtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhixing Feng Jose C. Clemente Brandon Wong Eric E. Schadt Detecting and phasing minor single-nucleotide variants from long-read sequencing data
description	Cellular genetic heterogeneity is common across biological conditions, yet application of long-read sequencing to this subject is limited by error rates. Here, the authors present iGDA, a tool for detection and phasing of minor variants from long-read sequencing data, allowing accurate reconstruction of haplotypes.
format	article
author	Zhixing Feng Jose C. Clemente Brandon Wong Eric E. Schadt
author_facet	Zhixing Feng Jose C. Clemente Brandon Wong Eric E. Schadt
author_sort	Zhixing Feng
title	Detecting and phasing minor single-nucleotide variants from long-read sequencing data
title_short	Detecting and phasing minor single-nucleotide variants from long-read sequencing data
title_full	Detecting and phasing minor single-nucleotide variants from long-read sequencing data
title_fullStr	Detecting and phasing minor single-nucleotide variants from long-read sequencing data
title_full_unstemmed	Detecting and phasing minor single-nucleotide variants from long-read sequencing data
title_sort	detecting and phasing minor single-nucleotide variants from long-read sequencing data
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/37aa516a22e74b34bed4e369ee1e4b98
work_keys_str_mv	AT zhixingfeng detectingandphasingminorsinglenucleotidevariantsfromlongreadsequencingdata AT josecclemente detectingandphasingminorsinglenucleotidevariantsfromlongreadsequencingdata AT brandonwong detectingandphasingminorsinglenucleotidevariantsfromlongreadsequencingdata AT ericeschadt detectingandphasingminorsinglenucleotidevariantsfromlongreadsequencingdata
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Detecting and phasing minor single-nucleotide variants from long-read sequencing data

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