Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

FHR1 is a serum protein implicated in complement regulation. Here the authors show that human FHR1 binds to necrotic cells, triggering inflammasome activation in monocytes in culture, localizes to necrotic tissue and correlates with inflammatory cytokine levels in vasculopathies.

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Autores principales:	Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel, Christine Skerka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37aad357dc58436e9dd86d7bd2bd62bb
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spelling	oai:doaj.org-article:37aad357dc58436e9dd86d7bd2bd62bb2021-12-02T14:38:46ZSerum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies10.1038/s41467-019-10766-02041-1723https://doaj.org/article/37aad357dc58436e9dd86d7bd2bd62bb2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10766-0https://doaj.org/toc/2041-1723FHR1 is a serum protein implicated in complement regulation. Here the authors show that human FHR1 binds to necrotic cells, triggering inflammasome activation in monocytes in culture, localizes to necrotic tissue and correlates with inflammatory cytokine levels in vasculopathies.Sarah IrmscherSilke R. BrixSvante L. H. ZipfelLuke D. HalderSibel MutlutürkSonia WulfEvaldas GirdauskasHermann ReichenspurnerRolf A. K. StahlBerit JungnickelThorsten WiechPeter F. ZipfelChristine SkerkaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah Irmscher Silke R. Brix Svante L. H. Zipfel Luke D. Halder Sibel Mutlutürk Sonia Wulf Evaldas Girdauskas Hermann Reichenspurner Rolf A. K. Stahl Berit Jungnickel Thorsten Wiech Peter F. Zipfel Christine Skerka Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies
description	FHR1 is a serum protein implicated in complement regulation. Here the authors show that human FHR1 binds to necrotic cells, triggering inflammasome activation in monocytes in culture, localizes to necrotic tissue and correlates with inflammatory cytokine levels in vasculopathies.
format	article
author	Sarah Irmscher Silke R. Brix Svante L. H. Zipfel Luke D. Halder Sibel Mutlutürk Sonia Wulf Evaldas Girdauskas Hermann Reichenspurner Rolf A. K. Stahl Berit Jungnickel Thorsten Wiech Peter F. Zipfel Christine Skerka
author_facet	Sarah Irmscher Silke R. Brix Svante L. H. Zipfel Luke D. Halder Sibel Mutlutürk Sonia Wulf Evaldas Girdauskas Hermann Reichenspurner Rolf A. K. Stahl Berit Jungnickel Thorsten Wiech Peter F. Zipfel Christine Skerka
author_sort	Sarah Irmscher
title	Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies
title_short	Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies
title_full	Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies
title_fullStr	Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies
title_full_unstemmed	Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies
title_sort	serum fhr1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/37aad357dc58436e9dd86d7bd2bd62bb
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Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

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