Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats

Abstract Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat many neuropsychiatric conditions. However, the mechanisms underlying its mode of action are still unclear. This is the first rodent study using resting-state functional MRI (rs-fMRI...

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Autores principales:	Bhedita J. Seewoo, Kirk W. Feindel, Sarah J. Etherington, Jennifer Rodger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37ad322e9f42455d9760deb19952cc17
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spelling	oai:doaj.org-article:37ad322e9f42455d9760deb19952cc172021-12-02T15:08:24ZResting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats10.1038/s41598-018-24951-62045-2322https://doaj.org/article/37ad322e9f42455d9760deb19952cc172018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24951-6https://doaj.org/toc/2045-2322Abstract Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat many neuropsychiatric conditions. However, the mechanisms underlying its mode of action are still unclear. This is the first rodent study using resting-state functional MRI (rs-fMRI) to examine low-intensity (LI) rTMS effects, in an effort to provide a direct means of comparison between rodent and human studies. Using anaesthetised Sprague-Dawley rats, rs-fMRI data were acquired before and after control or LI-rTMS at 1 Hz, 10 Hz, continuous theta burst stimulation (cTBS) or biomimetic high-frequency stimulation (BHFS). Independent component analysis revealed LI-rTMS-induced changes in the resting-state networks (RSN): (i) in the somatosensory cortex, the synchrony of resting activity decreased ipsilaterally following 10 Hz and bilaterally following 1 Hz stimulation and BHFS, and increased ipsilaterally following cTBS; (ii) the motor cortex showed bilateral changes following 1 Hz and 10 Hz stimulation, a contralateral decrease in synchrony following BHFS, and an ipsilateral increase following cTBS; and (iii) hippocampal synchrony decreased ipsilaterally following 10 Hz, and bilaterally following 1 Hz stimulation and BHFS. The present findings demonstrate that LI-rTMS modulates functional links within the rat RSN with frequency-specific outcomes, and the observed changes are similar to those described in humans following rTMS.Bhedita J. SeewooKirk W. FeindelSarah J. EtheringtonJennifer RodgerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bhedita J. Seewoo Kirk W. Feindel Sarah J. Etherington Jennifer Rodger Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats
description	Abstract Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat many neuropsychiatric conditions. However, the mechanisms underlying its mode of action are still unclear. This is the first rodent study using resting-state functional MRI (rs-fMRI) to examine low-intensity (LI) rTMS effects, in an effort to provide a direct means of comparison between rodent and human studies. Using anaesthetised Sprague-Dawley rats, rs-fMRI data were acquired before and after control or LI-rTMS at 1 Hz, 10 Hz, continuous theta burst stimulation (cTBS) or biomimetic high-frequency stimulation (BHFS). Independent component analysis revealed LI-rTMS-induced changes in the resting-state networks (RSN): (i) in the somatosensory cortex, the synchrony of resting activity decreased ipsilaterally following 10 Hz and bilaterally following 1 Hz stimulation and BHFS, and increased ipsilaterally following cTBS; (ii) the motor cortex showed bilateral changes following 1 Hz and 10 Hz stimulation, a contralateral decrease in synchrony following BHFS, and an ipsilateral increase following cTBS; and (iii) hippocampal synchrony decreased ipsilaterally following 10 Hz, and bilaterally following 1 Hz stimulation and BHFS. The present findings demonstrate that LI-rTMS modulates functional links within the rat RSN with frequency-specific outcomes, and the observed changes are similar to those described in humans following rTMS.
format	article
author	Bhedita J. Seewoo Kirk W. Feindel Sarah J. Etherington Jennifer Rodger
author_facet	Bhedita J. Seewoo Kirk W. Feindel Sarah J. Etherington Jennifer Rodger
author_sort	Bhedita J. Seewoo
title	Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats
title_short	Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats
title_full	Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats
title_fullStr	Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats
title_full_unstemmed	Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats
title_sort	resting-state fmri study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/37ad322e9f42455d9760deb19952cc17
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Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats

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