The Cytotoxicity and Clearance of Mutant Huntingtin and Other Misfolded Proteins

Protein misfolding and aggregation are implicated in many neurodegenerative diseases. One of these diseases is Huntington’s, which is caused by increased glutamine-encoding trinucleotide repeats within the Huntingtin gene. Like other misfolded proteins, mutated Huntingtin proteins with polyglutamine...

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Autores principales: Austin Folger, Yanchang Wang
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/37ae36b92d884b0494124a943a5f326f
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