Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers

Several challenges are involved in direct targeting of mutant p53, while targeting altered fitness of cells with loss of wild type p53 is an alternative approach. Here they identify niclosamide to be selectively toxic to p53 deficient cells through a previously unknown mitochondrial uncoupling mecha...

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Autores principales:	R. Kumar, L. Coronel, B. Somalanka, A. Raju, O. A. Aning, O. An, Y. S. Ho, S. Chen, S. Y. Mak, P. Y. Hor, H. Yang, M. Lakshmanan, H. Itoh, S. Y. Tan, Y. K. Lim, A. P. C. Wong, S. H. Chew, T. H. Huynh, B. C. Goh, C. Y. Lim, V. Tergaonkar, C. F. Cheok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37b449460c1b4f2d9a57f838a3deed30
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spelling	oai:doaj.org-article:37b449460c1b4f2d9a57f838a3deed302021-12-02T14:41:16ZMitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers10.1038/s41467-018-05805-12041-1723https://doaj.org/article/37b449460c1b4f2d9a57f838a3deed302018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05805-1https://doaj.org/toc/2041-1723Several challenges are involved in direct targeting of mutant p53, while targeting altered fitness of cells with loss of wild type p53 is an alternative approach. Here they identify niclosamide to be selectively toxic to p53 deficient cells through a previously unknown mitochondrial uncoupling mechanism.R. KumarL. CoronelB. SomalankaA. RajuO. A. AningO. AnY. S. HoS. ChenS. Y. MakP. Y. HorH. YangM. LakshmananH. ItohS. Y. TanY. K. LimA. P. C. WongS. H. ChewT. H. HuynhB. C. GohC. Y. LimV. TergaonkarC. F. CheokNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. Kumar L. Coronel B. Somalanka A. Raju O. A. Aning O. An Y. S. Ho S. Chen S. Y. Mak P. Y. Hor H. Yang M. Lakshmanan H. Itoh S. Y. Tan Y. K. Lim A. P. C. Wong S. H. Chew T. H. Huynh B. C. Goh C. Y. Lim V. Tergaonkar C. F. Cheok Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
description	Several challenges are involved in direct targeting of mutant p53, while targeting altered fitness of cells with loss of wild type p53 is an alternative approach. Here they identify niclosamide to be selectively toxic to p53 deficient cells through a previously unknown mitochondrial uncoupling mechanism.
format	article
author	R. Kumar L. Coronel B. Somalanka A. Raju O. A. Aning O. An Y. S. Ho S. Chen S. Y. Mak P. Y. Hor H. Yang M. Lakshmanan H. Itoh S. Y. Tan Y. K. Lim A. P. C. Wong S. H. Chew T. H. Huynh B. C. Goh C. Y. Lim V. Tergaonkar C. F. Cheok
author_facet	R. Kumar L. Coronel B. Somalanka A. Raju O. A. Aning O. An Y. S. Ho S. Chen S. Y. Mak P. Y. Hor H. Yang M. Lakshmanan H. Itoh S. Y. Tan Y. K. Lim A. P. C. Wong S. H. Chew T. H. Huynh B. C. Goh C. Y. Lim V. Tergaonkar C. F. Cheok
author_sort	R. Kumar
title	Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
title_short	Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
title_full	Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
title_fullStr	Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
title_full_unstemmed	Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
title_sort	mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/37b449460c1b4f2d9a57f838a3deed30
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Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers

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