Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy

Abstract The purpose of this study was to investigate whether baseline neutrophil to lymphocyte ratio (NLR) was an independent predictor for early symptomatic intracranial hemorrhage (sICH), poor functional outcome and mortality at 3 months after reperfusion therapy in acute ischemic stroke (AIS) pa...

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Autores principales:	Ying Bi, Jing Shen, Sheng-Cai Chen, Ji-Xiang Chen, Yuan-Peng Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37b65002ac8349dc8b1b7da91a47f00f
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spelling	oai:doaj.org-article:37b65002ac8349dc8b1b7da91a47f00f2021-12-02T17:05:11ZPrognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy10.1038/s41598-021-85373-52045-2322https://doaj.org/article/37b65002ac8349dc8b1b7da91a47f00f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85373-5https://doaj.org/toc/2045-2322Abstract The purpose of this study was to investigate whether baseline neutrophil to lymphocyte ratio (NLR) was an independent predictor for early symptomatic intracranial hemorrhage (sICH), poor functional outcome and mortality at 3 months after reperfusion therapy in acute ischemic stroke (AIS) patients. Using PubMed and EMBASE, we searched for literature published before January 19th, 2019. Two reviewers independently confirmed each study’s eligibility, assessed risk of bias, and extracted data. One reviewer combined studies using random effects meta-analysis. 9 studies with 3651 patients were pooled in the meta-analysis. Overall, baseline NLR levels were greater in patients with poor outcome. The standardized mean difference (SMD) in the NLR levels between patients with poor functional outcome (mRS > 2) and good functional outcome (mRS ≤ 2) was 0.54 units (95% credible interval [CI] [0.38, 0.70]). Heterogeneity test showed that there were significant differences between individual studies (p = 0.02; I2 = 72.8%). The NLR levels were associated with sICH in four included studies (n = 2003, SMD = 0.78, 95% [CI] [0.18, 1.38], I2 = 73.9%). Higher NLR levels were positively correlated with 3-month mortality (n = 1389, ES = 1.71, 95% CI [1.01,2.42], p < 0.01, I2 = 0%) when data were used as categorical variables. Our meta-analysis suggests that increased NLR levels are positively associated with greater risk of sICH, 3-month poor functional outcome and 3-month mortality in AIS patients undergoing reperfusion treatments. Although there are some deficits in this study, it may be feasible to predict the prognosis of reperfusion therapy in AIS patients with NLR levels.Ying BiJing ShenSheng-Cai ChenJi-Xiang ChenYuan-Peng XiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying Bi Jing Shen Sheng-Cai Chen Ji-Xiang Chen Yuan-Peng Xia Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy
description	Abstract The purpose of this study was to investigate whether baseline neutrophil to lymphocyte ratio (NLR) was an independent predictor for early symptomatic intracranial hemorrhage (sICH), poor functional outcome and mortality at 3 months after reperfusion therapy in acute ischemic stroke (AIS) patients. Using PubMed and EMBASE, we searched for literature published before January 19th, 2019. Two reviewers independently confirmed each study’s eligibility, assessed risk of bias, and extracted data. One reviewer combined studies using random effects meta-analysis. 9 studies with 3651 patients were pooled in the meta-analysis. Overall, baseline NLR levels were greater in patients with poor outcome. The standardized mean difference (SMD) in the NLR levels between patients with poor functional outcome (mRS > 2) and good functional outcome (mRS ≤ 2) was 0.54 units (95% credible interval [CI] [0.38, 0.70]). Heterogeneity test showed that there were significant differences between individual studies (p = 0.02; I2 = 72.8%). The NLR levels were associated with sICH in four included studies (n = 2003, SMD = 0.78, 95% [CI] [0.18, 1.38], I2 = 73.9%). Higher NLR levels were positively correlated with 3-month mortality (n = 1389, ES = 1.71, 95% CI [1.01,2.42], p < 0.01, I2 = 0%) when data were used as categorical variables. Our meta-analysis suggests that increased NLR levels are positively associated with greater risk of sICH, 3-month poor functional outcome and 3-month mortality in AIS patients undergoing reperfusion treatments. Although there are some deficits in this study, it may be feasible to predict the prognosis of reperfusion therapy in AIS patients with NLR levels.
format	article
author	Ying Bi Jing Shen Sheng-Cai Chen Ji-Xiang Chen Yuan-Peng Xia
author_facet	Ying Bi Jing Shen Sheng-Cai Chen Ji-Xiang Chen Yuan-Peng Xia
author_sort	Ying Bi
title	Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy
title_short	Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy
title_full	Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy
title_fullStr	Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy
title_full_unstemmed	Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy
title_sort	prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/37b65002ac8349dc8b1b7da91a47f00f
work_keys_str_mv	AT yingbi prognosticvalueofneutrophiltolymphocyteratioinacuteischemicstrokeafterreperfusiontherapy AT jingshen prognosticvalueofneutrophiltolymphocyteratioinacuteischemicstrokeafterreperfusiontherapy AT shengcaichen prognosticvalueofneutrophiltolymphocyteratioinacuteischemicstrokeafterreperfusiontherapy AT jixiangchen prognosticvalueofneutrophiltolymphocyteratioinacuteischemicstrokeafterreperfusiontherapy AT yuanpengxia prognosticvalueofneutrophiltolymphocyteratioinacuteischemicstrokeafterreperfusiontherapy
_version_	1718381784826118144

Prognostic value of neutrophil to lymphocyte ratio in acute ischemic stroke after reperfusion therapy

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