Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques

Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques

Oxidized phosphatidylcholines (oxPCs) are a structurally diverse class of lipids associated with various diseases. Here, the authors use mass spectrometry to construct a spectral library of 465 oxPCs and subsequently profile oxPCs formed during acetaminophen-induced acute liver failure in mice.

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Autores principales: Yuta Matsuoka, Masatomo Takahashi, Yuki Sugiura, Yoshihiro Izumi, Kazuhiro Nishiyama, Motohiro Nishida, Makoto Suematsu, Takeshi Bamba, Ken-ichi Yamada
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/37bab6945355410fb3f591261ec7e897
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spelling oai:doaj.org-article:37bab6945355410fb3f591261ec7e8972021-11-08T11:08:34ZStructural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques10.1038/s41467-021-26633-w2041-1723https://doaj.org/article/37bab6945355410fb3f591261ec7e8972021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26633-whttps://doaj.org/toc/2041-1723Oxidized phosphatidylcholines (oxPCs) are a structurally diverse class of lipids associated with various diseases. Here, the authors use mass spectrometry to construct a spectral library of 465 oxPCs and subsequently profile oxPCs formed during acetaminophen-induced acute liver failure in mice.Yuta MatsuokaMasatomo TakahashiYuki SugiuraYoshihiro IzumiKazuhiro NishiyamaMotohiro NishidaMakoto SuematsuTakeshi BambaKen-ichi YamadaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuta Matsuoka
Masatomo Takahashi
Yuki Sugiura
Yoshihiro Izumi
Kazuhiro Nishiyama
Motohiro Nishida
Makoto Suematsu
Takeshi Bamba
Ken-ichi Yamada
Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques
description Oxidized phosphatidylcholines (oxPCs) are a structurally diverse class of lipids associated with various diseases. Here, the authors use mass spectrometry to construct a spectral library of 465 oxPCs and subsequently profile oxPCs formed during acetaminophen-induced acute liver failure in mice.
format article
author Yuta Matsuoka
Masatomo Takahashi
Yuki Sugiura
Yoshihiro Izumi
Kazuhiro Nishiyama
Motohiro Nishida
Makoto Suematsu
Takeshi Bamba
Ken-ichi Yamada
author_facet Yuta Matsuoka
Masatomo Takahashi
Yuki Sugiura
Yoshihiro Izumi
Kazuhiro Nishiyama
Motohiro Nishida
Makoto Suematsu
Takeshi Bamba
Ken-ichi Yamada
author_sort Yuta Matsuoka
title Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques
title_short Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques
title_full Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques
title_fullStr Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques
title_full_unstemmed Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques
title_sort structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/37bab6945355410fb3f591261ec7e897
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