A computer study of the risk of cholesterol gallstone associated with obesity and normal weight

Abstract Obese people differ from the people of normal weight in gall bladder motility and have a higher risk of cholesterol stone formation. In this study, using a mathematical model of cholesterol homeostasis, which also considers the enterohepatic circulation of bile as well as cholesterol, we in...

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Autores principales:	Krystian Kubica, Joanna Balbus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37bb12bad5f14e36953932edc01807b4
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spelling	oai:doaj.org-article:37bb12bad5f14e36953932edc01807b42021-12-02T18:27:48ZA computer study of the risk of cholesterol gallstone associated with obesity and normal weight10.1038/s41598-021-88249-w2045-2322https://doaj.org/article/37bb12bad5f14e36953932edc01807b42021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88249-whttps://doaj.org/toc/2045-2322Abstract Obese people differ from the people of normal weight in gall bladder motility and have a higher risk of cholesterol stone formation. In this study, using a mathematical model of cholesterol homeostasis, which also considers the enterohepatic circulation of bile as well as cholesterol, we investigated the risk of cholesterol stone formation in obese and normal-weight groups who had normal blood cholesterol levels. We associated the risk of stone formation with the amount of cholesterol released into bile and the amount of de novo-synthesized cholic acid. For both groups, we determined the conditions of low and high risk. In addition, we analyzed the potential effects of changes in gall bladder motility with increased weight. The results showed that the obese group exhibited increased kinetics of enterohepatic circulation, leading to a significant increase in blood cholesterol levels, which can be reduced by increasing the amount of cholesterol in bile. Based on this finding, we suggest that for obese people, it is beneficial to reduce the amount and change the composition of circulating bile through the inhibition of cholic acid synthesis along with cholesterol synthesis. Furthermore, obese people should maintain a triglyceride-lowering diet and consume small meals containing fat, preferably in combination with agents that can reduce bile output from the gall bladder.Krystian KubicaJoanna BalbusNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Krystian Kubica Joanna Balbus A computer study of the risk of cholesterol gallstone associated with obesity and normal weight
description	Abstract Obese people differ from the people of normal weight in gall bladder motility and have a higher risk of cholesterol stone formation. In this study, using a mathematical model of cholesterol homeostasis, which also considers the enterohepatic circulation of bile as well as cholesterol, we investigated the risk of cholesterol stone formation in obese and normal-weight groups who had normal blood cholesterol levels. We associated the risk of stone formation with the amount of cholesterol released into bile and the amount of de novo-synthesized cholic acid. For both groups, we determined the conditions of low and high risk. In addition, we analyzed the potential effects of changes in gall bladder motility with increased weight. The results showed that the obese group exhibited increased kinetics of enterohepatic circulation, leading to a significant increase in blood cholesterol levels, which can be reduced by increasing the amount of cholesterol in bile. Based on this finding, we suggest that for obese people, it is beneficial to reduce the amount and change the composition of circulating bile through the inhibition of cholic acid synthesis along with cholesterol synthesis. Furthermore, obese people should maintain a triglyceride-lowering diet and consume small meals containing fat, preferably in combination with agents that can reduce bile output from the gall bladder.
format	article
author	Krystian Kubica Joanna Balbus
author_facet	Krystian Kubica Joanna Balbus
author_sort	Krystian Kubica
title	A computer study of the risk of cholesterol gallstone associated with obesity and normal weight
title_short	A computer study of the risk of cholesterol gallstone associated with obesity and normal weight
title_full	A computer study of the risk of cholesterol gallstone associated with obesity and normal weight
title_fullStr	A computer study of the risk of cholesterol gallstone associated with obesity and normal weight
title_full_unstemmed	A computer study of the risk of cholesterol gallstone associated with obesity and normal weight
title_sort	computer study of the risk of cholesterol gallstone associated with obesity and normal weight
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/37bb12bad5f14e36953932edc01807b4
work_keys_str_mv	AT krystiankubica acomputerstudyoftheriskofcholesterolgallstoneassociatedwithobesityandnormalweight AT joannabalbus acomputerstudyoftheriskofcholesterolgallstoneassociatedwithobesityandnormalweight AT krystiankubica computerstudyoftheriskofcholesterolgallstoneassociatedwithobesityandnormalweight AT joannabalbus computerstudyoftheriskofcholesterolgallstoneassociatedwithobesityandnormalweight
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A computer study of the risk of cholesterol gallstone associated with obesity and normal weight

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