HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation
Abstract Adverse birth outcomes are common in HIV-positive pregnant women receiving combination antiretroviral therapy (cART), especially when cART is initiated in early pregnancy. The mechanisms remain poorly understood. Using a mouse model we demonstrate that protease inhibitor based-cART exposure...
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Autores principales: | Hakimeh Mohammadi, Eszter Papp, Lindsay Cahill, Monique Rennie, Nicole Banko, Lakmini Pinnaduwage, Janice Lee, Mark Kibschull, Caroline Dunk, John G. Sled, Lena Serghides |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/37bf226f60dd4bb08d817725f3d25913 |
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