Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α

Golgi disassembly is required for mitosis and occurs by vesicle fusion suppression, although the mechanism is unclear. Here, Chang et al. show, with quantitative analyses and crystallography, that Importin-α regulates this process by blocking GM130-p115 interactions in a Ran pathway-independent way....

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Autores principales:	Chih-Chia Chang, Ching-Jou Chen, Cédric Grauffel, Yu-Chung Pien, Carmay Lim, Su-Yi Tsai, Kuo-Chiang Hsia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37bfbade8b014be484b0d47ceba4a971
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spelling	oai:doaj.org-article:37bfbade8b014be484b0d47ceba4a9712021-12-02T15:35:30ZRan pathway-independent regulation of mitotic Golgi disassembly by Importin-α10.1038/s41467-019-12207-42041-1723https://doaj.org/article/37bfbade8b014be484b0d47ceba4a9712019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12207-4https://doaj.org/toc/2041-1723Golgi disassembly is required for mitosis and occurs by vesicle fusion suppression, although the mechanism is unclear. Here, Chang et al. show, with quantitative analyses and crystallography, that Importin-α regulates this process by blocking GM130-p115 interactions in a Ran pathway-independent way.Chih-Chia ChangChing-Jou ChenCédric GrauffelYu-Chung PienCarmay LimSu-Yi TsaiKuo-Chiang HsiaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chih-Chia Chang Ching-Jou Chen Cédric Grauffel Yu-Chung Pien Carmay Lim Su-Yi Tsai Kuo-Chiang Hsia Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
description	Golgi disassembly is required for mitosis and occurs by vesicle fusion suppression, although the mechanism is unclear. Here, Chang et al. show, with quantitative analyses and crystallography, that Importin-α regulates this process by blocking GM130-p115 interactions in a Ran pathway-independent way.
format	article
author	Chih-Chia Chang Ching-Jou Chen Cédric Grauffel Yu-Chung Pien Carmay Lim Su-Yi Tsai Kuo-Chiang Hsia
author_facet	Chih-Chia Chang Ching-Jou Chen Cédric Grauffel Yu-Chung Pien Carmay Lim Su-Yi Tsai Kuo-Chiang Hsia
author_sort	Chih-Chia Chang
title	Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
title_short	Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
title_full	Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
title_fullStr	Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
title_full_unstemmed	Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
title_sort	ran pathway-independent regulation of mitotic golgi disassembly by importin-α
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/37bfbade8b014be484b0d47ceba4a971
work_keys_str_mv	AT chihchiachang ranpathwayindependentregulationofmitoticgolgidisassemblybyimportina AT chingjouchen ranpathwayindependentregulationofmitoticgolgidisassemblybyimportina AT cedricgrauffel ranpathwayindependentregulationofmitoticgolgidisassemblybyimportina AT yuchungpien ranpathwayindependentregulationofmitoticgolgidisassemblybyimportina AT carmaylim ranpathwayindependentregulationofmitoticgolgidisassemblybyimportina AT suyitsai ranpathwayindependentregulationofmitoticgolgidisassemblybyimportina AT kuochianghsia ranpathwayindependentregulationofmitoticgolgidisassemblybyimportina
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Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α

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