Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy

Interstitial brachytherapy (BT) is generally used for the treatment of well-confined solid tumors. One example of this is in the treatment of prostate tumors by permanent placement of radioactive seeds within the prostate gland, where low doses of radiation are delivered for several months. However,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Baljeet Seniwal, Velaphi C. Thipe, Sukhvir Singh, Telma C. F. Fonseca, Lucas Freitas de Freitas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	interstitial brachytherapy nanobrachytherapy radioactive nanoparticles intratumoral injection solid tumors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/37c0f6ae6c87455fb6b41ec4288dbdbe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:37c0f6ae6c87455fb6b41ec4288dbdbe
record_format	dspace
spelling	oai:doaj.org-article:37c0f6ae6c87455fb6b41ec4288dbdbe2021-11-30T16:57:00ZRecent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy2234-943X10.3389/fonc.2021.766407https://doaj.org/article/37c0f6ae6c87455fb6b41ec4288dbdbe2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.766407/fullhttps://doaj.org/toc/2234-943XInterstitial brachytherapy (BT) is generally used for the treatment of well-confined solid tumors. One example of this is in the treatment of prostate tumors by permanent placement of radioactive seeds within the prostate gland, where low doses of radiation are delivered for several months. However, successful implementation of this technique is hampered due to several posttreatment adverse effects or symptoms and operational and logistical complications associated with it. Recently, with the advancements in nanotechnology, radioactive nanoparticles (radio-NPs) functionalized with tumor-specific biomolecules, injected intratumorally, have been reported as an alternative to seed-based BT. Successful treatment of solid tumors using radio-NPs has been reported in several preclinical studies, on both mice and canine models. In this article, we review the recent advancements in the synthesis and use of radio-NPs as a substitute to seed-based BT. Here, we discuss the limitations of current seed-based BT and advantages of radio-NPs for BT applications. Recent progress on the types of radio-NPs, their features, synthesis methods, and delivery techniques are discussed. The last part of the review focuses on the currently used dosimetry protocols and studies on the dosimetry of nanobrachytherapy applications using radio-NPs. The current challenges and future research directions on the role of radio-NPs in BT treatments are also discussed.Baljeet SeniwalVelaphi C. ThipeVelaphi C. ThipeSukhvir SinghTelma C. F. FonsecaLucas Freitas de FreitasFrontiers Media S.A.articleinterstitial brachytherapynanobrachytherapyradioactive nanoparticlesintratumoral injectionsolid tumorsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interstitial brachytherapy nanobrachytherapy radioactive nanoparticles intratumoral injection solid tumors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	interstitial brachytherapy nanobrachytherapy radioactive nanoparticles intratumoral injection solid tumors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Baljeet Seniwal Velaphi C. Thipe Velaphi C. Thipe Sukhvir Singh Telma C. F. Fonseca Lucas Freitas de Freitas Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy
description	Interstitial brachytherapy (BT) is generally used for the treatment of well-confined solid tumors. One example of this is in the treatment of prostate tumors by permanent placement of radioactive seeds within the prostate gland, where low doses of radiation are delivered for several months. However, successful implementation of this technique is hampered due to several posttreatment adverse effects or symptoms and operational and logistical complications associated with it. Recently, with the advancements in nanotechnology, radioactive nanoparticles (radio-NPs) functionalized with tumor-specific biomolecules, injected intratumorally, have been reported as an alternative to seed-based BT. Successful treatment of solid tumors using radio-NPs has been reported in several preclinical studies, on both mice and canine models. In this article, we review the recent advancements in the synthesis and use of radio-NPs as a substitute to seed-based BT. Here, we discuss the limitations of current seed-based BT and advantages of radio-NPs for BT applications. Recent progress on the types of radio-NPs, their features, synthesis methods, and delivery techniques are discussed. The last part of the review focuses on the currently used dosimetry protocols and studies on the dosimetry of nanobrachytherapy applications using radio-NPs. The current challenges and future research directions on the role of radio-NPs in BT treatments are also discussed.
format	article
author	Baljeet Seniwal Velaphi C. Thipe Velaphi C. Thipe Sukhvir Singh Telma C. F. Fonseca Lucas Freitas de Freitas
author_facet	Baljeet Seniwal Velaphi C. Thipe Velaphi C. Thipe Sukhvir Singh Telma C. F. Fonseca Lucas Freitas de Freitas
author_sort	Baljeet Seniwal
title	Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy
title_short	Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy
title_full	Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy
title_fullStr	Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy
title_full_unstemmed	Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy
title_sort	recent advances in brachytherapy using radioactive nanoparticles: an alternative to seed-based brachytherapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/37c0f6ae6c87455fb6b41ec4288dbdbe
work_keys_str_mv	AT baljeetseniwal recentadvancesinbrachytherapyusingradioactivenanoparticlesanalternativetoseedbasedbrachytherapy AT velaphicthipe recentadvancesinbrachytherapyusingradioactivenanoparticlesanalternativetoseedbasedbrachytherapy AT velaphicthipe recentadvancesinbrachytherapyusingradioactivenanoparticlesanalternativetoseedbasedbrachytherapy AT sukhvirsingh recentadvancesinbrachytherapyusingradioactivenanoparticlesanalternativetoseedbasedbrachytherapy AT telmacffonseca recentadvancesinbrachytherapyusingradioactivenanoparticlesanalternativetoseedbasedbrachytherapy AT lucasfreitasdefreitas recentadvancesinbrachytherapyusingradioactivenanoparticlesanalternativetoseedbasedbrachytherapy
_version_	1718406437766430720

Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy

Ejemplares similares