Bio-inspired flexible artificial synapses for pain perception and nerve injuries

Abstract Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces. However, a prominent challenge is to emulate the functions of the biological synapse, which is the basic building block of the ne...

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Autores principales:	Qifeng Lu, Fuqin Sun, Lin Liu, Lianhui Li, Mingming Hao, Zihao Wang, Ting Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Electronics TK7800-8360 Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/37c5564994a74df391a3d87db8c7f594
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spelling	oai:doaj.org-article:37c5564994a74df391a3d87db8c7f5942021-12-02T13:58:30ZBio-inspired flexible artificial synapses for pain perception and nerve injuries10.1038/s41528-020-0066-02397-4621https://doaj.org/article/37c5564994a74df391a3d87db8c7f5942020-03-01T00:00:00Zhttps://doi.org/10.1038/s41528-020-0066-0https://doaj.org/toc/2397-4621Abstract Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces. However, a prominent challenge is to emulate the functions of the biological synapse, which is the basic building block of the neural system. Here, inspired by the pain perception mechanism of the living creatures, a flexible double-layer memristor was constructed, with 90% semiconducting single-wall carbon nanotubes (s-SWCNTs) covered by LiClO4 doped polyoxyethylene oxide (PEO: LiClO4) as the channel materials. The carriers (protons and Li+) from PEO: LiClO4 imitated the functions of Na+ and K+ in biological systems. A potentiation of the post-synaptic signal was observed with mild stimuli, while the post-synaptic signal was inhibited with severe stimuli with a pulse voltage larger than 1.4 V in this research. These behaviors resemble the sensation of pain, neuroprotection, and possible injuries to the neural system. To explore the underlying mechanism of the phenomenon, the fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Raman spectrum, and current (IV) sweep were carried out. It was inferred that the observed results are attributable to the interaction between carriers in PEO: LiClO4 and functional groups and defects in the s-SWCNTs. The enhanced channel current results from the fulfillment of the traps by the carriers, and the suppression of the current is due to the intercalation of Li+ in the s-SWCNTs. This flexible artificial synapse opens a new avenue for the construction of biocompatible electronic devices towards artificial intelligence systems.Qifeng LuFuqin SunLin LiuLianhui LiMingming HaoZihao WangTing ZhangNature PortfolioarticleElectronicsTK7800-8360Materials of engineering and construction. Mechanics of materialsTA401-492ENnpj Flexible Electronics, Vol 4, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Electronics TK7800-8360 Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Electronics TK7800-8360 Materials of engineering and construction. Mechanics of materials TA401-492 Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Mingming Hao Zihao Wang Ting Zhang Bio-inspired flexible artificial synapses for pain perception and nerve injuries
description	Abstract Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces. However, a prominent challenge is to emulate the functions of the biological synapse, which is the basic building block of the neural system. Here, inspired by the pain perception mechanism of the living creatures, a flexible double-layer memristor was constructed, with 90% semiconducting single-wall carbon nanotubes (s-SWCNTs) covered by LiClO4 doped polyoxyethylene oxide (PEO: LiClO4) as the channel materials. The carriers (protons and Li+) from PEO: LiClO4 imitated the functions of Na+ and K+ in biological systems. A potentiation of the post-synaptic signal was observed with mild stimuli, while the post-synaptic signal was inhibited with severe stimuli with a pulse voltage larger than 1.4 V in this research. These behaviors resemble the sensation of pain, neuroprotection, and possible injuries to the neural system. To explore the underlying mechanism of the phenomenon, the fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Raman spectrum, and current (IV) sweep were carried out. It was inferred that the observed results are attributable to the interaction between carriers in PEO: LiClO4 and functional groups and defects in the s-SWCNTs. The enhanced channel current results from the fulfillment of the traps by the carriers, and the suppression of the current is due to the intercalation of Li+ in the s-SWCNTs. This flexible artificial synapse opens a new avenue for the construction of biocompatible electronic devices towards artificial intelligence systems.
format	article
author	Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Mingming Hao Zihao Wang Ting Zhang
author_facet	Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Mingming Hao Zihao Wang Ting Zhang
author_sort	Qifeng Lu
title	Bio-inspired flexible artificial synapses for pain perception and nerve injuries
title_short	Bio-inspired flexible artificial synapses for pain perception and nerve injuries
title_full	Bio-inspired flexible artificial synapses for pain perception and nerve injuries
title_fullStr	Bio-inspired flexible artificial synapses for pain perception and nerve injuries
title_full_unstemmed	Bio-inspired flexible artificial synapses for pain perception and nerve injuries
title_sort	bio-inspired flexible artificial synapses for pain perception and nerve injuries
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/37c5564994a74df391a3d87db8c7f594
work_keys_str_mv	AT qifenglu bioinspiredflexibleartificialsynapsesforpainperceptionandnerveinjuries AT fuqinsun bioinspiredflexibleartificialsynapsesforpainperceptionandnerveinjuries AT linliu bioinspiredflexibleartificialsynapsesforpainperceptionandnerveinjuries AT lianhuili bioinspiredflexibleartificialsynapsesforpainperceptionandnerveinjuries AT mingminghao bioinspiredflexibleartificialsynapsesforpainperceptionandnerveinjuries AT zihaowang bioinspiredflexibleartificialsynapsesforpainperceptionandnerveinjuries AT tingzhang bioinspiredflexibleartificialsynapsesforpainperceptionandnerveinjuries
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Bio-inspired flexible artificial synapses for pain perception and nerve injuries

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