Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.

<h4>Objective</h4>Late-life depression and subjective cognitive decline (SCD) are significant risk factors for dementia. However, studies with a large sample size are needed to clarify their independent and combined risks for subsequent dementia.<h4>Methods</h4>This nationwid...

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Autores principales:	Sheng-Min Wang, Kyung-do Han, Nak-Young Kim, Yoo Hyun Um, Dong-Woo Kang, Hae-Ran Na, Chang-Uk Lee, Hyun Kook Lim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37c851873e944ea9811dd8ce76c8b4f1
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spelling	oai:doaj.org-article:37c851873e944ea9811dd8ce76c8b4f12021-12-02T20:07:03ZLate-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.1932-620310.1371/journal.pone.0254639https://doaj.org/article/37c851873e944ea9811dd8ce76c8b4f12021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254639https://doaj.org/toc/1932-6203<h4>Objective</h4>Late-life depression and subjective cognitive decline (SCD) are significant risk factors for dementia. However, studies with a large sample size are needed to clarify their independent and combined risks for subsequent dementia.<h4>Methods</h4>This nationwide population-based cohort study included all individuals aged 66 years who participated in the National Screening Program between 2009 and 2013 (N = 939,099). Subjects were followed from the day they underwent screening to the diagnosis of dementia, death, or the last follow-up day (December 31, 2017).<h4>Results</h4>Depressive symptom presentation, recent depressive disorder, and SCD independently increased dementia incidence with adjusted hazard ratio (aHR) of 1.286 (95% CI:1.255-1.318), 1.697 (95% CI:1.621-1.776), and 1.748 (95% CI: 689-1.808) respectively. Subjects having both SCD and depression had a higher risk (aHR = 2.466, 95% CI:2.383-2.551) of dementia than having depression (aHR = 1.402, 95% CI:1.364-1.441) or SCD (aHR = 1.748, 95% CI:1.689-1.808) alone.<h4>Conclusions</h4>Depressive symptoms, depressive disorder, and SCD are independent risk factors for dementia. Co-occurring depression and SCD have an additive effect on the risk of dementia; thus, early intervention and close follow up are necessary for patients with co-occurring SCD and depression.Sheng-Min WangKyung-do HanNak-Young KimYoo Hyun UmDong-Woo KangHae-Ran NaChang-Uk LeeHyun Kook LimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254639 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sheng-Min Wang Kyung-do Han Nak-Young Kim Yoo Hyun Um Dong-Woo Kang Hae-Ran Na Chang-Uk Lee Hyun Kook Lim Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.
description	<h4>Objective</h4>Late-life depression and subjective cognitive decline (SCD) are significant risk factors for dementia. However, studies with a large sample size are needed to clarify their independent and combined risks for subsequent dementia.<h4>Methods</h4>This nationwide population-based cohort study included all individuals aged 66 years who participated in the National Screening Program between 2009 and 2013 (N = 939,099). Subjects were followed from the day they underwent screening to the diagnosis of dementia, death, or the last follow-up day (December 31, 2017).<h4>Results</h4>Depressive symptom presentation, recent depressive disorder, and SCD independently increased dementia incidence with adjusted hazard ratio (aHR) of 1.286 (95% CI:1.255-1.318), 1.697 (95% CI:1.621-1.776), and 1.748 (95% CI: 689-1.808) respectively. Subjects having both SCD and depression had a higher risk (aHR = 2.466, 95% CI:2.383-2.551) of dementia than having depression (aHR = 1.402, 95% CI:1.364-1.441) or SCD (aHR = 1.748, 95% CI:1.689-1.808) alone.<h4>Conclusions</h4>Depressive symptoms, depressive disorder, and SCD are independent risk factors for dementia. Co-occurring depression and SCD have an additive effect on the risk of dementia; thus, early intervention and close follow up are necessary for patients with co-occurring SCD and depression.
format	article
author	Sheng-Min Wang Kyung-do Han Nak-Young Kim Yoo Hyun Um Dong-Woo Kang Hae-Ran Na Chang-Uk Lee Hyun Kook Lim
author_facet	Sheng-Min Wang Kyung-do Han Nak-Young Kim Yoo Hyun Um Dong-Woo Kang Hae-Ran Na Chang-Uk Lee Hyun Kook Lim
author_sort	Sheng-Min Wang
title	Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.
title_short	Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.
title_full	Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.
title_fullStr	Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.
title_full_unstemmed	Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.
title_sort	late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: a nationwide longitudinal study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/37c851873e944ea9811dd8ce76c8b4f1
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Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.

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