Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung

<i>Background and Objectives</i>: Telomeric zinc finger-associated protein (TZAP) is a telomere regulation protein, previously known as ZBTB48. It binds preferentially to elongated telomeres, competing with telomeric repeat factors 1 and 2. TZAP expression may be associated with carcinog...

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Autores principales:	Gun-Jik Kim, Jae-Ho Lee, Mincheol Chae, Deok-Heon Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	TZAP telomere lung cancer ZBTB48 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/37cad0281be44653b190723e1ec114e2
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spelling	oai:doaj.org-article:37cad0281be44653b190723e1ec114e22021-11-25T18:18:44ZPrognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung10.3390/medicina571112231648-91441010-660Xhttps://doaj.org/article/37cad0281be44653b190723e1ec114e22021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1223https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives</i>: Telomeric zinc finger-associated protein (TZAP) is a telomere regulation protein, previously known as ZBTB48. It binds preferentially to elongated telomeres, competing with telomeric repeat factors 1 and 2. TZAP expression may be associated with carcinogenesis, however; this study has not yet been performed in lung cancer. In this study, we examined the clinicopathological and prognostic values of TZAP expression in non-small cell lung cancer (NSCLC). <i>Materials and Methods:</i> Data were collected from The Cancer Genome Atlas. The clinical and prognostic values of TZAP for NSCLC were examined in adenocarcinoma (AD) and squamous cell carcinoma (SCC). <i>Results:</i> TZAP expression significantly increased in NSCLC tissues compared with normal tissues. In AD, TZAP expression was lower in patients with higher T stage (<i>p</i> = 0.005), and was associated with lymph node stage in SCC (<i>p</i> = 0.005). Survival analysis showed shorter disease-free survival in AD patients with lower TZAP expression (<i>p</i> = 0.047). TZAP expression did not have other clinical or prognostic value for AD and SCC. <i>Conclusions</i>: TZAP expression is a potential prognostic marker for NSCLC, especially in patients with AD.Gun-Jik KimJae-Ho LeeMincheol ChaeDeok-Heon LeeMDPI AGarticleTZAPtelomerelung cancerZBTB48Medicine (General)R5-920ENMedicina, Vol 57, Iss 1223, p 1223 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TZAP telomere lung cancer ZBTB48 Medicine (General) R5-920
spellingShingle	TZAP telomere lung cancer ZBTB48 Medicine (General) R5-920 Gun-Jik Kim Jae-Ho Lee Mincheol Chae Deok-Heon Lee Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung
description	<i>Background and Objectives</i>: Telomeric zinc finger-associated protein (TZAP) is a telomere regulation protein, previously known as ZBTB48. It binds preferentially to elongated telomeres, competing with telomeric repeat factors 1 and 2. TZAP expression may be associated with carcinogenesis, however; this study has not yet been performed in lung cancer. In this study, we examined the clinicopathological and prognostic values of TZAP expression in non-small cell lung cancer (NSCLC). <i>Materials and Methods:</i> Data were collected from The Cancer Genome Atlas. The clinical and prognostic values of TZAP for NSCLC were examined in adenocarcinoma (AD) and squamous cell carcinoma (SCC). <i>Results:</i> TZAP expression significantly increased in NSCLC tissues compared with normal tissues. In AD, TZAP expression was lower in patients with higher T stage (<i>p</i> = 0.005), and was associated with lymph node stage in SCC (<i>p</i> = 0.005). Survival analysis showed shorter disease-free survival in AD patients with lower TZAP expression (<i>p</i> = 0.047). TZAP expression did not have other clinical or prognostic value for AD and SCC. <i>Conclusions</i>: TZAP expression is a potential prognostic marker for NSCLC, especially in patients with AD.
format	article
author	Gun-Jik Kim Jae-Ho Lee Mincheol Chae Deok-Heon Lee
author_facet	Gun-Jik Kim Jae-Ho Lee Mincheol Chae Deok-Heon Lee
author_sort	Gun-Jik Kim
title	Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung
title_short	Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung
title_full	Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung
title_fullStr	Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung
title_full_unstemmed	Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung
title_sort	prognostic value of telomeric zinc finger-associated protein expression in adenocarcinoma and squamous cell carcinoma of lung
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/37cad0281be44653b190723e1ec114e2
work_keys_str_mv	AT gunjikkim prognosticvalueoftelomericzincfingerassociatedproteinexpressioninadenocarcinomaandsquamouscellcarcinomaoflung AT jaeholee prognosticvalueoftelomericzincfingerassociatedproteinexpressioninadenocarcinomaandsquamouscellcarcinomaoflung AT mincheolchae prognosticvalueoftelomericzincfingerassociatedproteinexpressioninadenocarcinomaandsquamouscellcarcinomaoflung AT deokheonlee prognosticvalueoftelomericzincfingerassociatedproteinexpressioninadenocarcinomaandsquamouscellcarcinomaoflung
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Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung

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