Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer

Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer

The multistep processes involved in the evolution of inflammation to invasive esophageal squamous cell carcinoma (ESCC) is unclear. Here, the authors report a mouse model of ESCC and the role of interplay between carcinogen-transformed epithelial cells and their microenvironment in ESCC development.

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Detalles Bibliográficos
Autores principales: Jiacheng Yao, Qionghua Cui, Wenyi Fan, Yuling Ma, Yamei Chen, Tianyuan Liu, Xiannian Zhang, Yiyi Xi, Chengcheng Wang, Linna Peng, Yingying Luo, Ai Lin, Wenjia Guo, Lin Lin, Yuan Lin, Wen Tan, Dongxin Lin, Chen Wu, Jianbin Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/37cc999bc41b4082b5c5f89652f95a3b
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Descripción
Sumario:The multistep processes involved in the evolution of inflammation to invasive esophageal squamous cell carcinoma (ESCC) is unclear. Here, the authors report a mouse model of ESCC and the role of interplay between carcinogen-transformed epithelial cells and their microenvironment in ESCC development.

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