Activity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections

Background: Upper respiratory tract infections occupy a leading position in the infectious pathology. According to the World Health Organization (WHO), up to 500 million people fall ill with acute respiratory infections in the world every year, of which 2 million people die from various complication...

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Autores principales:	Tatiana S. Petrenko, Irina A. Novikova, Olga V. Denisova, Vyacheslav M. Devichenskiy
Formato:	article
Lenguaje:	RU
Publicado:	Eco-vector 2021
Materias:	oral fluid luminal-dependent chemiluminescence prooxidant antioxidant Medicine R
Acceso en línea:	https://doaj.org/article/37cd4e2ae92b4f9fad9482cb76e9db78
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spelling	oai:doaj.org-article:37cd4e2ae92b4f9fad9482cb76e9db782021-11-30T18:15:21ZActivity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections2220-30952618-862710.17816/clinpract65014https://doaj.org/article/37cd4e2ae92b4f9fad9482cb76e9db782021-07-01T00:00:00Zhttps://journals.eco-vector.com/clinpractice/article/viewFile/65014/pdfhttps://doaj.org/toc/2220-3095https://doaj.org/toc/2618-8627Background: Upper respiratory tract infections occupy a leading position in the infectious pathology. According to the World Health Organization (WHO), up to 500 million people fall ill with acute respiratory infections in the world every year, of which 2 million people die from various complications. At the same time, a number of researchers note the lack of methods for clinical and laboratory assessment of the condition of patients with this pathology. Aims: To evaluate the parameters of free radical oxidation in oral fluid of patients with recurrent upper respiratory tract infections (RIURT). Methods: The study involved 64 apparently healthy people who suffered respiratory infections up to 2 times a year, and 85 patients with RIURT (4 or more times a year), who at the time of the study were in remission. The determination of the parameters of the pro / antioxidant systems was carried out using two methods (photometric: the content of lipid peroxidation products and the level of ceruloplasmin and luminol-dependent chemiluminescence (LDCL) were measured, making it possible to assess the complex interaction of two systems prooxidants and antioxidants). Results: The studies have demonstrated that, for most of the RIURT patients during remission, the levels of certain prooxidant components (diene conjugates, ketodienes, Schiff bases), as well as of an oral fluid antioxidant (ADS: ceruloplasmin) were elevated compared to the controls. At the same time, the LDCL parameters of oral fluid did not go beyond the reference interval, although they were changed relative to the median of the control group. This allows us to consider the observed fluctuations as a balance in the system of pro- and antioxidants. Conclusions. The use of oral fluid as a biological material for the assessment of the pro-/antioxidant system opens up new possibilities in the diagnosis of respiratory disease.Tatiana S. PetrenkoIrina A. NovikovaOlga V. DenisovaVyacheslav M. DevichenskiyEco-vectorarticleoral fluidluminal-dependent chemiluminescenceprooxidantantioxidantMedicineRRUКлиническая практика , Vol 12, Iss 2, Pp 39-46 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	oral fluid luminal-dependent chemiluminescence prooxidant antioxidant Medicine R
spellingShingle	oral fluid luminal-dependent chemiluminescence prooxidant antioxidant Medicine R Tatiana S. Petrenko Irina A. Novikova Olga V. Denisova Vyacheslav M. Devichenskiy Activity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections
description	Background: Upper respiratory tract infections occupy a leading position in the infectious pathology. According to the World Health Organization (WHO), up to 500 million people fall ill with acute respiratory infections in the world every year, of which 2 million people die from various complications. At the same time, a number of researchers note the lack of methods for clinical and laboratory assessment of the condition of patients with this pathology. Aims: To evaluate the parameters of free radical oxidation in oral fluid of patients with recurrent upper respiratory tract infections (RIURT). Methods: The study involved 64 apparently healthy people who suffered respiratory infections up to 2 times a year, and 85 patients with RIURT (4 or more times a year), who at the time of the study were in remission. The determination of the parameters of the pro / antioxidant systems was carried out using two methods (photometric: the content of lipid peroxidation products and the level of ceruloplasmin and luminol-dependent chemiluminescence (LDCL) were measured, making it possible to assess the complex interaction of two systems prooxidants and antioxidants). Results: The studies have demonstrated that, for most of the RIURT patients during remission, the levels of certain prooxidant components (diene conjugates, ketodienes, Schiff bases), as well as of an oral fluid antioxidant (ADS: ceruloplasmin) were elevated compared to the controls. At the same time, the LDCL parameters of oral fluid did not go beyond the reference interval, although they were changed relative to the median of the control group. This allows us to consider the observed fluctuations as a balance in the system of pro- and antioxidants. Conclusions. The use of oral fluid as a biological material for the assessment of the pro-/antioxidant system opens up new possibilities in the diagnosis of respiratory disease.
format	article
author	Tatiana S. Petrenko Irina A. Novikova Olga V. Denisova Vyacheslav M. Devichenskiy
author_facet	Tatiana S. Petrenko Irina A. Novikova Olga V. Denisova Vyacheslav M. Devichenskiy
author_sort	Tatiana S. Petrenko
title	Activity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections
title_short	Activity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections
title_full	Activity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections
title_fullStr	Activity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections
title_full_unstemmed	Activity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections
title_sort	activity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections
publisher	Eco-vector
publishDate	2021
url	https://doaj.org/article/37cd4e2ae92b4f9fad9482cb76e9db78
work_keys_str_mv	AT tatianaspetrenko activityoffreeradicalprocessesinoralfluidofpatientswithrecurrentupperrespiratorytractinfections AT irinaanovikova activityoffreeradicalprocessesinoralfluidofpatientswithrecurrentupperrespiratorytractinfections AT olgavdenisova activityoffreeradicalprocessesinoralfluidofpatientswithrecurrentupperrespiratorytractinfections AT vyacheslavmdevichenskiy activityoffreeradicalprocessesinoralfluidofpatientswithrecurrentupperrespiratorytractinfections
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Activity of free radical processes in oral fluid of patients with recurrent upper respiratory tract infections

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