MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep

Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic μ-opioid receptor agonist and can provide constant post-operative analgesia for up to 72 h. The aim of this study was to determine the reduction of the minimum alveolar concentration of sevoflurane (MACSEVO) by tr...

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Autores principales:	Lauren Duffee, Eraldo Passino Sanna, Antonio Scanu, Nicolò Columbano
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	minimum alveolar concentration (mac) sevoflurane sheep transdermal fentanyl Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/37d01420e87b4ea592bfcd07e292428c
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spelling	oai:doaj.org-article:37d01420e87b4ea592bfcd07e292428c2021-11-17T21:27:52ZMAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep1820-744810.2478/acve-2018-0015https://doaj.org/article/37d01420e87b4ea592bfcd07e292428c2018-06-01T00:00:00Zhttps://doi.org/10.2478/acve-2018-0015https://doaj.org/toc/1820-7448Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic μ-opioid receptor agonist and can provide constant post-operative analgesia for up to 72 h. The aim of this study was to determine the reduction of the minimum alveolar concentration of sevoflurane (MACSEVO) by transdermal fentanyl in nonpregnant ewes. Nine sheep were mask induced with sevoflurane (SEVO in oxygen). MACSEVO determinations involved electrical current applied to the lateral metacarpus as a supramaximal stimulus and measurements in duplicate. Seven days later, a fentanyl patch (75 μg/h) was applied to each sheep and 15.1 ± 1.8 h later the MAC re-determined (MACSF). MACSF was 1.99 ± 0.32 %, corresponding to 25.6 ± 8.1 % reduction from MACSEVO (P < 0.001). Transdermal fentanyl produces a significant MACSEVO-sparing effect with minimal effect on cardiovascular parameters.Lauren DuffeeEraldo Passino SannaAntonio ScanuNicolò ColumbanoSciendoarticleminimum alveolar concentration (mac)sevofluranesheeptransdermal fentanylVeterinary medicineSF600-1100ENActa Veterinaria, Vol 68, Iss 2, Pp 211-216 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	minimum alveolar concentration (mac) sevoflurane sheep transdermal fentanyl Veterinary medicine SF600-1100
spellingShingle	minimum alveolar concentration (mac) sevoflurane sheep transdermal fentanyl Veterinary medicine SF600-1100 Lauren Duffee Eraldo Passino Sanna Antonio Scanu Nicolò Columbano MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep
description	Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic μ-opioid receptor agonist and can provide constant post-operative analgesia for up to 72 h. The aim of this study was to determine the reduction of the minimum alveolar concentration of sevoflurane (MACSEVO) by transdermal fentanyl in nonpregnant ewes. Nine sheep were mask induced with sevoflurane (SEVO in oxygen). MACSEVO determinations involved electrical current applied to the lateral metacarpus as a supramaximal stimulus and measurements in duplicate. Seven days later, a fentanyl patch (75 μg/h) was applied to each sheep and 15.1 ± 1.8 h later the MAC re-determined (MACSF). MACSF was 1.99 ± 0.32 %, corresponding to 25.6 ± 8.1 % reduction from MACSEVO (P < 0.001). Transdermal fentanyl produces a significant MACSEVO-sparing effect with minimal effect on cardiovascular parameters.
format	article
author	Lauren Duffee Eraldo Passino Sanna Antonio Scanu Nicolò Columbano
author_facet	Lauren Duffee Eraldo Passino Sanna Antonio Scanu Nicolò Columbano
author_sort	Lauren Duffee
title	MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep
title_short	MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep
title_full	MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep
title_fullStr	MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep
title_full_unstemmed	MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep
title_sort	mac-sparing effect of transdermal fentanyl in sevoflurane-anesthetized sheep
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/37d01420e87b4ea592bfcd07e292428c
work_keys_str_mv	AT laurenduffee macsparingeffectoftransdermalfentanylinsevofluraneanesthetizedsheep AT eraldopassinosanna macsparingeffectoftransdermalfentanylinsevofluraneanesthetizedsheep AT antonioscanu macsparingeffectoftransdermalfentanylinsevofluraneanesthetizedsheep AT nicolocolumbano macsparingeffectoftransdermalfentanylinsevofluraneanesthetizedsheep
_version_	1718425277076340736

MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep

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