Child Weight Gain Trajectories Linked To Oral Microbiota Composition

Abstract Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children. Here we analyzed the gut and oral microbiota of 226 two-year-olds with 16S rRNA gene sequencing. Weight and length were measured at...

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Autores principales:	Sarah J. C. Craig, Daniel Blankenberg, Alice Carla Luisa Parodi, Ian M. Paul, Leann L. Birch, Jennifer S. Savage, Michele E. Marini, Jennifer L. Stokes, Anton Nekrutenko, Matthew Reimherr, Francesca Chiaromonte, Kateryna D. Makova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Oral Microbiota Rapid Infant Weight Gain Linear Discriminant Analysis Effect Size (LEfSe) Diet-related Variables Microbiota Samples Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37d37598cbcb426fad0a4be9bcc52903
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spelling	oai:doaj.org-article:37d37598cbcb426fad0a4be9bcc529032021-12-02T15:08:53ZChild Weight Gain Trajectories Linked To Oral Microbiota Composition10.1038/s41598-018-31866-92045-2322https://doaj.org/article/37d37598cbcb426fad0a4be9bcc529032018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31866-9https://doaj.org/toc/2045-2322Abstract Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children. Here we analyzed the gut and oral microbiota of 226 two-year-olds with 16S rRNA gene sequencing. Weight and length were measured at seven time points and used to identify children with rapid infant weight gain (a strong risk factor for childhood obesity), and to derive growth curves with innovative Functional Data Analysis (FDA) techniques. We showed that growth curves were associated negatively with diversity, and positively with the Firmicutes-to-Bacteroidetes ratio, of the oral microbiota. We also demonstrated an association between the gut microbiota and child growth, even after controlling for the effect of diet on the microbiota. Lastly, we identified several bacterial genera that were associated with child growth patterns. These results suggest that by the age of two, the oral microbiota of children with rapid infant weight gain may have already begun to establish patterns often seen in obese adults. They also suggest that the gut microbiota at age two, while strongly influenced by diet, does not harbor obesity signatures many researchers identified in later life stages.Sarah J. C. CraigDaniel BlankenbergAlice Carla Luisa ParodiIan M. PaulLeann L. BirchJennifer S. SavageMichele E. MariniJennifer L. StokesAnton NekrutenkoMatthew ReimherrFrancesca ChiaromonteKateryna D. MakovaNature PortfolioarticleOral MicrobiotaRapid Infant Weight GainLinear Discriminant Analysis Effect Size (LEfSe)Diet-related VariablesMicrobiota SamplesMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oral Microbiota Rapid Infant Weight Gain Linear Discriminant Analysis Effect Size (LEfSe) Diet-related Variables Microbiota Samples Medicine R Science Q
spellingShingle	Oral Microbiota Rapid Infant Weight Gain Linear Discriminant Analysis Effect Size (LEfSe) Diet-related Variables Microbiota Samples Medicine R Science Q Sarah J. C. Craig Daniel Blankenberg Alice Carla Luisa Parodi Ian M. Paul Leann L. Birch Jennifer S. Savage Michele E. Marini Jennifer L. Stokes Anton Nekrutenko Matthew Reimherr Francesca Chiaromonte Kateryna D. Makova Child Weight Gain Trajectories Linked To Oral Microbiota Composition
description	Abstract Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children. Here we analyzed the gut and oral microbiota of 226 two-year-olds with 16S rRNA gene sequencing. Weight and length were measured at seven time points and used to identify children with rapid infant weight gain (a strong risk factor for childhood obesity), and to derive growth curves with innovative Functional Data Analysis (FDA) techniques. We showed that growth curves were associated negatively with diversity, and positively with the Firmicutes-to-Bacteroidetes ratio, of the oral microbiota. We also demonstrated an association between the gut microbiota and child growth, even after controlling for the effect of diet on the microbiota. Lastly, we identified several bacterial genera that were associated with child growth patterns. These results suggest that by the age of two, the oral microbiota of children with rapid infant weight gain may have already begun to establish patterns often seen in obese adults. They also suggest that the gut microbiota at age two, while strongly influenced by diet, does not harbor obesity signatures many researchers identified in later life stages.
format	article
author	Sarah J. C. Craig Daniel Blankenberg Alice Carla Luisa Parodi Ian M. Paul Leann L. Birch Jennifer S. Savage Michele E. Marini Jennifer L. Stokes Anton Nekrutenko Matthew Reimherr Francesca Chiaromonte Kateryna D. Makova
author_facet	Sarah J. C. Craig Daniel Blankenberg Alice Carla Luisa Parodi Ian M. Paul Leann L. Birch Jennifer S. Savage Michele E. Marini Jennifer L. Stokes Anton Nekrutenko Matthew Reimherr Francesca Chiaromonte Kateryna D. Makova
author_sort	Sarah J. C. Craig
title	Child Weight Gain Trajectories Linked To Oral Microbiota Composition
title_short	Child Weight Gain Trajectories Linked To Oral Microbiota Composition
title_full	Child Weight Gain Trajectories Linked To Oral Microbiota Composition
title_fullStr	Child Weight Gain Trajectories Linked To Oral Microbiota Composition
title_full_unstemmed	Child Weight Gain Trajectories Linked To Oral Microbiota Composition
title_sort	child weight gain trajectories linked to oral microbiota composition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/37d37598cbcb426fad0a4be9bcc52903
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Child Weight Gain Trajectories Linked To Oral Microbiota Composition

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