Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression

Non-secretory multiple myeloma is a rare form of the disease that presents a diagnostic challenge. A 69-year-old woman presented to the emergency department with a pathological fracture of the right clavicle, along with a history of asthenia and middle back pain in the preceding three months. Workup...

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Autores principales:	Miguel Silva, Joana Martins, João Pinto, Teresina Amaro
Formato:	article
Lenguaje:	EN PT
Publicado:	Ordem dos Médicos 2021
Materias:	fractures, spontaneous keratins multiple myeloma plasma cells Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/37d74ab19cbb4928829bf1e30280850d
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spelling	oai:doaj.org-article:37d74ab19cbb4928829bf1e30280850d2021-12-01T21:03:58ZNon-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression0870-399X1646-075810.20344/amp.13235https://doaj.org/article/37d74ab19cbb4928829bf1e30280850d2021-11-01T00:00:00Zhttps://actamedicaportuguesa.com/revista/index.php/amp/article/view/13235https://doaj.org/toc/0870-399Xhttps://doaj.org/toc/1646-0758Non-secretory multiple myeloma is a rare form of the disease that presents a diagnostic challenge. A 69-year-old woman presented to the emergency department with a pathological fracture of the right clavicle, along with a history of asthenia and middle back pain in the preceding three months. Workup revealed multiple focal lytic bone lesions in the clavicles, ribs, skull and thoracic- lumbar-sacral spine, without evidence of anemia, hypercalcemia or renal failure, with no abnormal immunofixation in the serum or urine and with normal serum free light chain ratios. The Iliac crest bone marrow aspiration and biopsy revealed a scarcely involved marrow, However, biopsy of one of the focal bone lesions revealed a hypercellular bone marrow with phenotypically abnormal plasmocytes, along with an intriguing, albeit aberrant, cytokeratin expression. Non-secretory multiple myeloma is in itself a rare diagnosis. However, the combination of a patchy marrow involvement and aberrant cytokeratin expression makes this a noteworthy presentation.Miguel SilvaJoana MartinsJoão PintoTeresina AmaroOrdem dos Médicosarticlefractures, spontaneouskeratinsmultiple myelomaplasma cellsMedicineRMedicine (General)R5-920ENPTActa Médica Portuguesa, Vol 34, Iss 11, Pp 778-781 (2021)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	fractures, spontaneous keratins multiple myeloma plasma cells Medicine R Medicine (General) R5-920
spellingShingle	fractures, spontaneous keratins multiple myeloma plasma cells Medicine R Medicine (General) R5-920 Miguel Silva Joana Martins João Pinto Teresina Amaro Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression
description	Non-secretory multiple myeloma is a rare form of the disease that presents a diagnostic challenge. A 69-year-old woman presented to the emergency department with a pathological fracture of the right clavicle, along with a history of asthenia and middle back pain in the preceding three months. Workup revealed multiple focal lytic bone lesions in the clavicles, ribs, skull and thoracic- lumbar-sacral spine, without evidence of anemia, hypercalcemia or renal failure, with no abnormal immunofixation in the serum or urine and with normal serum free light chain ratios. The Iliac crest bone marrow aspiration and biopsy revealed a scarcely involved marrow, However, biopsy of one of the focal bone lesions revealed a hypercellular bone marrow with phenotypically abnormal plasmocytes, along with an intriguing, albeit aberrant, cytokeratin expression. Non-secretory multiple myeloma is in itself a rare diagnosis. However, the combination of a patchy marrow involvement and aberrant cytokeratin expression makes this a noteworthy presentation.
format	article
author	Miguel Silva Joana Martins João Pinto Teresina Amaro
author_facet	Miguel Silva Joana Martins João Pinto Teresina Amaro
author_sort	Miguel Silva
title	Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression
title_short	Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression
title_full	Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression
title_fullStr	Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression
title_full_unstemmed	Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression
title_sort	non-secretory multiple myeloma with patchy marrow involvement and aberrant cytokeratin expression
publisher	Ordem dos Médicos
publishDate	2021
url	https://doaj.org/article/37d74ab19cbb4928829bf1e30280850d
work_keys_str_mv	AT miguelsilva nonsecretorymultiplemyelomawithpatchymarrowinvolvementandaberrantcytokeratinexpression AT joanamartins nonsecretorymultiplemyelomawithpatchymarrowinvolvementandaberrantcytokeratinexpression AT joaopinto nonsecretorymultiplemyelomawithpatchymarrowinvolvementandaberrantcytokeratinexpression AT teresinaamaro nonsecretorymultiplemyelomawithpatchymarrowinvolvementandaberrantcytokeratinexpression
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Non-Secretory Multiple Myeloma with Patchy Marrow Involvement and Aberrant Cytokeratin Expression

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