89Zr-pro-MMP-9 F(ab′)2 detects colitis induced intestinal and kidney fibrosis

Abstract Intestinal fibrosis is a common complication of inflammatory bowel disease but remains difficult to detect. Matrix metalloproteases (MMPs) have key roles in fibrosis and are therefore potential targets for fibrosis detection. We determined whether immunoPET of F(ab′)2 antibody fragments tar...

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Autores principales: Nicole Dmochowska, William Tieu, Marianne D. Keller, Courtney A. Hollis, Melissa A. Campaniello, Chris Mavrangelos, Prab Takhar, Patrick A. Hughes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/37d95436984e45b4b6bac1118dadc677
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