Whole-genome optical mapping of bone-marrow myeloma cells reveals association of extramedullary multiple myeloma with chromosome 1 abnormalities

Whole-genome optical mapping of bone-marrow myeloma cells reveals association of extramedullary multiple myeloma with chromosome 1 abnormalities

Abstract Extramedullary disease (EMM) represents a rare, aggressive and mostly resistant phenotype of multiple myeloma (MM). EMM is frequently associated with high-risk cytogenetics, but their complex genomic architecture is largely unexplored. We used whole-genome optical mapping (Saphyr, Bionano G...

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Main Authors: Eva Kriegova, Regina Fillerova, Jiri Minarik, Jakub Savara, Jirina Manakova, Anna Petrackova, Martin Dihel, Jana Balcarkova, Petra Krhovska, Tomas Pika, Petr Gajdos, Marek Behalek, Michal Vasinek, Tomas Papajik
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/37daeaba58954dc38da078cfcf51a94f
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