Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.

Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7,8-tetrachlorodibenzo[p]dioxin, TCDD) to promote e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Michael K Skinner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37dd3ad3bc65410b84650cb512b68d9d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:37dd3ad3bc65410b84650cb512b68d9d
record_format	dspace
spelling	oai:doaj.org-article:37dd3ad3bc65410b84650cb512b68d9d2021-11-18T08:13:50ZDioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.1932-620310.1371/journal.pone.0046249https://doaj.org/article/37dd3ad3bc65410b84650cb512b68d9d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049995/?tool=EBIhttps://doaj.org/toc/1932-6203Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7,8-tetrachlorodibenzo[p]dioxin, TCDD) to promote epigenetic transgenerational inheritance of disease and DNA methylation epimutations in sperm. Gestating F0 generation females were exposed to dioxin during fetal day 8 to 14 and adult-onset disease was evaluated in F1 and F3 generation rats. The incidences of total disease and multiple disease increased in F1 and F3 generations. Prostate disease, ovarian primordial follicle loss and polycystic ovary disease were increased in F1 generation dioxin lineage. Kidney disease in males, pubertal abnormalities in females, ovarian primordial follicle loss and polycystic ovary disease were increased in F3 generation dioxin lineage animals. Analysis of the F3 generation sperm epigenome identified 50 differentially DNA methylated regions (DMR) in gene promoters. These DMR provide potential epigenetic biomarkers for transgenerational disease and ancestral environmental exposures. Observations demonstrate dioxin exposure of a gestating female promotes epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.Mohan ManikkamRebecca TraceyCarlos Guerrero-BosagnaMichael K SkinnerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e46249 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohan Manikkam Rebecca Tracey Carlos Guerrero-Bosagna Michael K Skinner Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.
description	Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7,8-tetrachlorodibenzo[p]dioxin, TCDD) to promote epigenetic transgenerational inheritance of disease and DNA methylation epimutations in sperm. Gestating F0 generation females were exposed to dioxin during fetal day 8 to 14 and adult-onset disease was evaluated in F1 and F3 generation rats. The incidences of total disease and multiple disease increased in F1 and F3 generations. Prostate disease, ovarian primordial follicle loss and polycystic ovary disease were increased in F1 generation dioxin lineage. Kidney disease in males, pubertal abnormalities in females, ovarian primordial follicle loss and polycystic ovary disease were increased in F3 generation dioxin lineage animals. Analysis of the F3 generation sperm epigenome identified 50 differentially DNA methylated regions (DMR) in gene promoters. These DMR provide potential epigenetic biomarkers for transgenerational disease and ancestral environmental exposures. Observations demonstrate dioxin exposure of a gestating female promotes epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.
format	article
author	Mohan Manikkam Rebecca Tracey Carlos Guerrero-Bosagna Michael K Skinner
author_facet	Mohan Manikkam Rebecca Tracey Carlos Guerrero-Bosagna Michael K Skinner
author_sort	Mohan Manikkam
title	Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.
title_short	Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.
title_full	Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.
title_fullStr	Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.
title_full_unstemmed	Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.
title_sort	dioxin (tcdd) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/37dd3ad3bc65410b84650cb512b68d9d
work_keys_str_mv	AT mohanmanikkam dioxintcddinducesepigenetictransgenerationalinheritanceofadultonsetdiseaseandspermepimutations AT rebeccatracey dioxintcddinducesepigenetictransgenerationalinheritanceofadultonsetdiseaseandspermepimutations AT carlosguerrerobosagna dioxintcddinducesepigenetictransgenerationalinheritanceofadultonsetdiseaseandspermepimutations AT michaelkskinner dioxintcddinducesepigenetictransgenerationalinheritanceofadultonsetdiseaseandspermepimutations
_version_	1718422035799998464

Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations.

Ejemplares similares