IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells

XLP-2 syndrome is caused by XIAP mutation. Here the authors show that mouse and human XIAP-deficient regulatory T cells have defective suppressive function as a result of conversion to proinflammatory cytokine producing cells, an effect that can be prevented by blocking the IL-6 receptor.

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Autores principales:	Wan-Chen Hsieh, Tzu-Sheng Hsu, Ya-Jen Chang, Ming-Zong Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/37de1a9a384e45eba015976455f5d58b
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spelling	oai:doaj.org-article:37de1a9a384e45eba015976455f5d58b2021-12-02T15:34:45ZIL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells10.1038/s41467-018-02862-42041-1723https://doaj.org/article/37de1a9a384e45eba015976455f5d58b2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02862-4https://doaj.org/toc/2041-1723XLP-2 syndrome is caused by XIAP mutation. Here the authors show that mouse and human XIAP-deficient regulatory T cells have defective suppressive function as a result of conversion to proinflammatory cytokine producing cells, an effect that can be prevented by blocking the IL-6 receptor.Wan-Chen HsiehTzu-Sheng HsuYa-Jen ChangMing-Zong LaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wan-Chen Hsieh Tzu-Sheng Hsu Ya-Jen Chang Ming-Zong Lai IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
description	XLP-2 syndrome is caused by XIAP mutation. Here the authors show that mouse and human XIAP-deficient regulatory T cells have defective suppressive function as a result of conversion to proinflammatory cytokine producing cells, an effect that can be prevented by blocking the IL-6 receptor.
format	article
author	Wan-Chen Hsieh Tzu-Sheng Hsu Ya-Jen Chang Ming-Zong Lai
author_facet	Wan-Chen Hsieh Tzu-Sheng Hsu Ya-Jen Chang Ming-Zong Lai
author_sort	Wan-Chen Hsieh
title	IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_short	IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_full	IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_fullStr	IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_full_unstemmed	IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
title_sort	il-6 receptor blockade corrects defects of xiap-deficient regulatory t cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/37de1a9a384e45eba015976455f5d58b
work_keys_str_mv	AT wanchenhsieh il6receptorblockadecorrectsdefectsofxiapdeficientregulatorytcells AT tzushenghsu il6receptorblockadecorrectsdefectsofxiapdeficientregulatorytcells AT yajenchang il6receptorblockadecorrectsdefectsofxiapdeficientregulatorytcells AT mingzonglai il6receptorblockadecorrectsdefectsofxiapdeficientregulatorytcells
_version_	1718386774560997376

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells

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