DIAGNOSTIC ACCURACY OF PLASMA LACTATE IN NEONATAL BIRTH ASPHYXIA

Objective: To find out the diagnostic accuracy of levels of plasma lactate in neonatal birth asphyxia by taking pH as gold standard. Study Design: Cross sectional validation study. Place and Duration of Study: The study was conducted at Paediatrics Department, Pak Emirates Military Hospital Rawal...

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Autores principales:	Adnan Halim, Abdul Wahid Hussain, Isbah Gul, Madiha Halim, Farhan Halim, Salman Ali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	plasma lactate neonatal birth asphyxia Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/37de1d4ead6643bb86c876216808e6da
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spelling	oai:doaj.org-article:37de1d4ead6643bb86c876216808e6da2021-11-15T04:53:59ZDIAGNOSTIC ACCURACY OF PLASMA LACTATE IN NEONATAL BIRTH ASPHYXIA0030-96482411-8842https://doaj.org/article/37de1d4ead6643bb86c876216808e6da2019-04-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2485/2042https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To find out the diagnostic accuracy of levels of plasma lactate in neonatal birth asphyxia by taking pH as gold standard. Study Design: Cross sectional validation study. Place and Duration of Study: The study was conducted at Paediatrics Department, Pak Emirates Military Hospital Rawalpindi, from May to Nov 2013. Material and Methods: Two Hundred and forty neonates were selected through non-probability purposive sampling after informed consent from parents by inclusion and exclusion criteria. The sample size was calculated by WHO calculator. The plasma lactate and pH of the neonates were taken within first six hours of delivery of child. The samples were sent in heparinized containers along with ice packs and were stored at 0°C to -2°C. Results: Gestational age of 52.5% (n=126) neonates was between 34-37 weeks while 47.5% (n=114) was between 38-40 weeks with a mean of 37.75 ± 2.91 weeks. Gender distribution among neonates showed that 58.75% (n=141) male and 41.25% (n=99) females. The diagnostic accuracy of plasma lactate in neonatal birth asphyxia by taking pH as gold standard showed 194 (80.83%) true positive, 7 (2.92%) false positive, 31 (12.92%) true negative and 8 (3.33%) were false negative. The test has sensitivity = 96.04%, specificity = 81.58%, positive predictive value= 96.52%, negative predictive value = 81.58% and accuracy of 93.75%. Conclusion: There was a higher diagnostic accuracy of plasma lactate by taking pH as gold standard for the diagnosis of neonatal birth asphyxia.Adnan HalimAbdul Wahid HussainIsbah GulMadiha HalimFarhan HalimSalman AliArmy Medical College Rawalpindiarticleplasma lactateneonatal birth asphyxiaMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 1, Pp 4-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	plasma lactate neonatal birth asphyxia Medicine R Medicine (General) R5-920
spellingShingle	plasma lactate neonatal birth asphyxia Medicine R Medicine (General) R5-920 Adnan Halim Abdul Wahid Hussain Isbah Gul Madiha Halim Farhan Halim Salman Ali DIAGNOSTIC ACCURACY OF PLASMA LACTATE IN NEONATAL BIRTH ASPHYXIA
description	Objective: To find out the diagnostic accuracy of levels of plasma lactate in neonatal birth asphyxia by taking pH as gold standard. Study Design: Cross sectional validation study. Place and Duration of Study: The study was conducted at Paediatrics Department, Pak Emirates Military Hospital Rawalpindi, from May to Nov 2013. Material and Methods: Two Hundred and forty neonates were selected through non-probability purposive sampling after informed consent from parents by inclusion and exclusion criteria. The sample size was calculated by WHO calculator. The plasma lactate and pH of the neonates were taken within first six hours of delivery of child. The samples were sent in heparinized containers along with ice packs and were stored at 0°C to -2°C. Results: Gestational age of 52.5% (n=126) neonates was between 34-37 weeks while 47.5% (n=114) was between 38-40 weeks with a mean of 37.75 ± 2.91 weeks. Gender distribution among neonates showed that 58.75% (n=141) male and 41.25% (n=99) females. The diagnostic accuracy of plasma lactate in neonatal birth asphyxia by taking pH as gold standard showed 194 (80.83%) true positive, 7 (2.92%) false positive, 31 (12.92%) true negative and 8 (3.33%) were false negative. The test has sensitivity = 96.04%, specificity = 81.58%, positive predictive value= 96.52%, negative predictive value = 81.58% and accuracy of 93.75%. Conclusion: There was a higher diagnostic accuracy of plasma lactate by taking pH as gold standard for the diagnosis of neonatal birth asphyxia.
format	article
author	Adnan Halim Abdul Wahid Hussain Isbah Gul Madiha Halim Farhan Halim Salman Ali
author_facet	Adnan Halim Abdul Wahid Hussain Isbah Gul Madiha Halim Farhan Halim Salman Ali
author_sort	Adnan Halim
title	DIAGNOSTIC ACCURACY OF PLASMA LACTATE IN NEONATAL BIRTH ASPHYXIA
title_short	DIAGNOSTIC ACCURACY OF PLASMA LACTATE IN NEONATAL BIRTH ASPHYXIA
title_full	DIAGNOSTIC ACCURACY OF PLASMA LACTATE IN NEONATAL BIRTH ASPHYXIA
title_fullStr	DIAGNOSTIC ACCURACY OF PLASMA LACTATE IN NEONATAL BIRTH ASPHYXIA
title_full_unstemmed	DIAGNOSTIC ACCURACY OF PLASMA LACTATE IN NEONATAL BIRTH ASPHYXIA
title_sort	diagnostic accuracy of plasma lactate in neonatal birth asphyxia
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/37de1d4ead6643bb86c876216808e6da
work_keys_str_mv	AT adnanhalim diagnosticaccuracyofplasmalactateinneonatalbirthasphyxia AT abdulwahidhussain diagnosticaccuracyofplasmalactateinneonatalbirthasphyxia AT isbahgul diagnosticaccuracyofplasmalactateinneonatalbirthasphyxia AT madihahalim diagnosticaccuracyofplasmalactateinneonatalbirthasphyxia AT farhanhalim diagnosticaccuracyofplasmalactateinneonatalbirthasphyxia AT salmanali diagnosticaccuracyofplasmalactateinneonatalbirthasphyxia
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DIAGNOSTIC ACCURACY OF PLASMA LACTATE IN NEONATAL BIRTH ASPHYXIA

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