Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
Although important for early development, PU.1 is dispensable for mature B cell function, possibly owing to compensation by the related transcription factor SpiB. Here the authors show PU.1 and SpiB are collectively required for humoral immunity, through regulation of germinal centre formation and p...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/37dfa3d4d0b943728cbf40939c1d7a57 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Although important for early development, PU.1 is dispensable for mature B cell function, possibly owing to compensation by the related transcription factor SpiB. Here the authors show PU.1 and SpiB are collectively required for humoral immunity, through regulation of germinal centre formation and plasma cell differentiation. |
|---|